For the investigational use of Adipose Derived
Stem Cells (ADSC's) for clinical research and deployment.
J Immunol. 2009 Jun 15;182(12):8015-25 Authors: Kanayama M, Kurotaki D, Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suzuki K, Harada T, Li HM, Uehara J, Miyazaki T, Minami A, Kon S, Uede T Osteopontin is critically involved in rheumatoid arthritis; however, the molecular cross-talk between osteopontin…
Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii54-7 Authors: Guillevin L Vasculitis can occur either as a primary condition or secondary to CTDs, infection, medication or malignancy. This article reviews the clinical presentation and management of vascular disease associated with SLE and SS, as well as the primary necrotizing vasculitides. Although pulmonary arterial hypertension (PAH) has traditionally…
Mod Rheumatol. 2009;19(4):379-83 Authors: Nanke Y, Kawamoto M, Yago T, Chiba J, Yamanaka H, Kotake S Fluvastatin (Fluv) is reported to induce apoptosis in rheumatoid arthritis (RA) synoviocytes through the blocking of protein geranylgeranylation. We report here our investigation of whether geranylgeranylacetone (GGA) induces cell death in RA synoviocytes. Synovial tissues were obtained from patients…
Rheumatology (Oxford). 2009 Oct;48(10):1185-9 Authors: Bouffi C, Djouad F, Mathieu M, Noël D, Jorgensen C Multipotent mesenchymal stromal cells (MSCs) have raised interest mainly because of cartilage/bone differentiation potential which is now partly eclipsed by their capacity to counteract inflammation and suppress host immune responses as well as to prevent fibrosis. MSCs have been identified…
Nat Rev Rheumatol. 2009 Jul;5(7):392-9 Authors: Djouad F, Bouffi C, Ghannam S, Noël D, Jorgensen C Mesenchymal stem cells (MSCs), or multipotent mesenchymal stromal cells as they are also known, have been identified in bone marrow as well as in other tissues of the joint, including adipose, synovium, periosteum, perichondrium, and cartilage. These cells are…
Mod Rheumatol. 2009;19(5):522-9 Authors: Terabe F, Kitano M, Kawai M, Kuwahara Y, Hirano T, Arimitsu J, Hagihara K, Shima Y, Narazaki M, Tanaka T, Kawase I, Sano H, Ogata A Overgrowth of the synovium plays an important role in the pathogenesis of rheumatoid arthritis (RA). Platelet-derived growth factor (PDGF) is one of the most potent…
Arthritis Rheum. 2009 Aug;60(8):2284-93 Authors: Muhammad K, Roll P, Einsele H, Dörner T, Tony HP OBJECTIVE: Transient B cell depletion by rituximab has been used with clinical efficacy in the treatment of patients with rheumatoid arthritis (RA). Previous studies of B cell repopulation have shown long-term numerical reduction in memory B cells. Non-class-switched IgD+CD27+ memory…
Clin Lab. 2009;55(5-6):235-41 Authors: Marković M, Majkić-Singh N, Ignjatović S Patients with rheumatoid arthritis often conduct bathing in hot mineral water with a high concentrations of sulfate compounds in the water and ambient air. We investigated the effect of hyperthermia and sulfur as possible stress factors at transcriptional level in several proinflammatory genes in fibroblast…
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Jul;25(7):606-8, 611 Authors: Mao XD, Sun SJ, Pei ZY, Zhang LH AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). METHODS: RASF were pretreated with TP…
Arthritis Res Ther. 2009;11(5):R138 Authors: Thwin MM, Douni E, Arjunan P, Kollias G, Kumar PV, Gopalakrishnakone P INTRODUCTION: Secretory phospholipase A2 (sPLA2) and matrix metalloproteinase (MMP) inhibitors are potent modulators of inflammation with therapeutic potential, but have limited efficacy in rheumatoid arthritis (RA). The objective of this study was to understand the inhibitory mechanism of…
