A two-year follow-up study of co-transplantation with neural stem/precursor cells and mesenchymal stromal cells in ischemic stroke patients.

Stem cell therapy is an emerging therapeutic modality in the treatment of stroke. We assessed the safety and feasibility of the co-transplantation of neural stem/precursor cells (NSPCs) and mesenchymal stromal cells (MSCs) in patients with ischemic stroke. Eight patients were enrolled in this study. All patients had a hemisphere with infarct lesions located on one…

Cell Surgical Network Study for Stromal Vascular Fraction Registered by ClinicalTrials.gov

Rancho Mirage, CA (PRWEB) October 14, 2013 Clinicaltrials.gov, a service of the U.S. National Institutes of Health has registered on their public site an IRB approved safety study from the Cell Surgical Network, Inc.. This study is available for patients with various degenerative and inflammatory conditions to undergo Stromal Vascular Fraction deployment for the evaluation and for the…

Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy.

Cytotherapy. 2011 Jan 13. [Epub ahead of print] Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Ikegame Y, Yamashita K, Hayashi SI, Mizuno H, Tawada M, You F, Yamada K, Tanaka Y, Egashira Y, Nakashima S, Yoshimura SI, Iwama T. Source Department of Neurosurgery, Gifu University Graduate School…

A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke.

Cells. 2010 Jun;28(6):1099-106 A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. • Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY, • We previously evaluated the short-term follow-up preliminary data of mesenchymal stem cells (MSCs) transplantation in patients with ischemic stroke. The present study…

• Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats.

• J Transl Med. 2010;8:63 • Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. • Leu S, Lin YC, Yuen CM, Yen CH, Kao YH, Sun CK, Yip HK • BACKGROUND: The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status…

Stem cells in human neurodegenerative disorders–time for clinical translation?

J Clin Invest. 2010 Jan 4;120(1):29-40 Stem cells in human neurodegenerative disorders–time for clinical translation? Lindvall O, Kokaia Z Stem cell-based approaches have received much hype as potential treatments for neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in animal models of neurodegenerative diseases can improve function by replacing the lost neurons and…

The potential of mesenchymal stem cells for neural repair.

Discov Med. 2010 Mar;9(46):236-42. The potential of mesenchymal stem cells for neural repair. Miller RH, Bai L, Lennon DP, Caplan AI. Source Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. rhm3@case.edu Abstract Developing effective therapies for serious neurological insults remains…

Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macacafascicularis.

Brain Res. 2010 Jun 2;1334:65-72. Epub 2010 Mar 28. Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macacafascicularis. Li J, Zhu H, Liu Y, Li Q, Lu S, Feng M, Xu Y, Huang L, Ma C, An Y, Zhao RC, Wang R, Qin C. Source Institute of Laboratory…