Multipotent mesenchymal stromal cells for autoimmune diseases: teaching new dogs old tricks.

Multipotent mesenchymal stromal cells for autoimmune diseases: teaching new dogs old tricks. Tyndall A, Uccelli A. Source Department of Rheumatology, University of Basel, University Rheumatology Clinic, Basel, Switzerland. alan.tyndall@fps-basel.ch Abstract MSCs, otherwise known as multipotent mesenchymal stromal cells, are being examined for the treatment of autoimmune disease (AD) on the basis of their in vitro…

Diffuse alopecia with stem cell folliculitis: chronic diffuse alopecia areata or a distinct entity?

Am J Dermatopathol. 1999 Feb;21(1):46-50. Diffuse alopecia with stem cell folliculitis: chronic diffuse alopecia areata or a distinct entity? Kossard S. Source Skin and Cancer Foundation, Darlinghurst, NSW, Australia. Abstract A 34-year-old woman presented with an 8-year history of slowly progressive diffuse nonscarring alopecia with loss of hair density. Scalp biopsy specimens showed increased miniaturized…

Potential involvement of the stem cell factor receptor c-kit in alopecia areata and androgenetic alopecia: histopathological, immunohistochemical, and semiquantitative investigations.

Acta Histochem Cytochem. 2010 Feb 27;43(1):9-17. Epub 2010 Feb 26. Potential involvement of the stem cell factor receptor c-kit in alopecia areata and androgenetic alopecia: histopathological, immunohistochemical, and semiquantitative investigations. Ashrafuzzaman M, Yamamoto T, Shibata N, Hirayama TT, Kobayashi M. Source Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan. drashrafprs@yahoo.com Abstract Alopecia areata (AAR)…

Hair follicle is a target of stress hormone and autoimmune reactions.

J Dermatol Sci. 2010 Nov;60(2):67-73. Epub 2010 Sep 29. Hair follicle is a target of stress hormone and autoimmune reactions. Ito T. Source Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-1192, Japan. itoutai@hama-med.ac.jp Abstract Interest in the hair follicle (HF) has recently increased, yet the detailed mechanisms of HF function…

Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata.

Eur J Dermatol. 2011 Mar-Apr;21(2):209-12. Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata. Amoh Y, Maejima H, Niiyama S, Mii S, Hamada Y, Saito N, Katsuoka K. Source Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan. Abstract Cells that are nestin positive and keratin 15…

Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata.

J Eur Acad Dermatol Venereol. 2011 Nov;25(11):1346-50. doi: 10.1111/j.1468-3083.2010.03956.x. Epub 2010 Dec 29. Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata. Yoshida R, Tanaka K, Amagai M, Ohyama M. Source Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. Abstract BACKGROUND:…

Alopecia Areata

Alopecia Areata is a genetically related auto-immune condition in which the body attacks its own hair follicles resulting in small bald patches. It can involve the entire scalp (totalis) or the entire body (universalis). Sometimes patients spontaneously improve and others continue to worsen. Steroid therapy and topical immune-suppressants are frequently used for treatment. There are…

Regulation of TNFalpha and IL1beta in rheumatoid arthritis synovial fibroblasts by leukotriene B4.

Rheumatol Int. 2010 Jul;30(9):1183-9 Authors: Xu S, Lu H, Lin J, Chen Z, Jiang D Arachidonic acid metabolites, such as leukotriene B4 (LTB4), are known to play an important role in pathogenesis of rheumatoid arthritis (RA). Apart from leukocytes, RA synovial fibroblasts (RASF) produce a broad array of inflammatory mediators to recruit, retain and activate…

Monoclonal antibodies: new therapeutic agents for autoimmune hemolytic anemia?

Endocr Metab Immune Disord Drug Targets. 2008 Mar;8(1):62-8 Authors: D’Arena G, Taylor RP, Cascavilla N, Lindorfer MA Conventional treatment of autoimmune hemolytic anemia (AIHA) comprises corticosteroids and splenectomy and/or other immunosuppressive drugs for refractory/relapsed patients. Monoclonal antibodies (MoAbs) rituximab and alemtuzumab have gained widespread acceptance in the management of B-cell malignancies. More recently, they have…