Category Archives: Auto-Immune Diseases Library

Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts.

Biochem Biophys Res Commun. 2008 Jun 13;370(4):599-602 Authors: Palmer CD, Mutch BE, Page TH, Horwood NJ, Foxwell BM Discordant cytokine production is characteristic of chronic inflammatory conditions like rheumatoid arthritis (RA), and anti-cytokine therapeutics are becoming routinely used to treat RA in the clinic. Fibroblasts from rheumatoid synovium have been shown to contribute to cytokine…

Rheumatoid arthritis and cardiovascular disease.

Curr Atheroscler Rep. 2008 Apr;10(2):128-33 Authors: Dhawan SS, Quyyumi AA Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease affecting approximately 1% of the adult general population. Cardiovascular disease is recognized as the leading cause of death in RA patients, accounting for nearly 40% of their mortality. Patients with RA are at a twofold increased…

Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways.

Mod Rheumatol. 2008;18(4):366-78 Authors: Okuma-Yoshioka C, Seto H, Kadono Y, Hikita A, Oshima Y, Kurosawa H, Nakamura K, Tanaka S We previously reported that synovial fibroblast-like cells (SFs) can be differentiated into chondrocytes through activin receptor-like kinase (ALK) 3 activation. The aim of this study was to clarify the effect and signaling pathways of tumor…

Multipotent mesenchymal stromal cells in articular diseases.

Best Pract Res Clin Rheumatol. 2008 Apr;22(2):269-84 Authors: Jorgensen C, Djouad F, Bouffi C, Mrugala D, Noël D Although cartilage defects are common features of osteoarthritis and rheumatoid arthritis, current treatments can rarely restore the full function of native cartilage. Recent studies have provided new perspectives for cartilage engineering using multipotent mesenchymal stromal cells (MSC).…

Evaluation of COX-1/COX-2 selectivity and potency of a new class of COX-2 inhibitors.

Eur J Pharmacol. 2008 Jun 24;588(1):93-8 Authors: Gierse J, Nickols M, Leahy K, Warner J, Zhang Y, Cortes-Burgos L, Carter J, Seibert K, Masferrer J A new class of selective cyclooxygenase-2 (COX-2) inhibitors has been identified by high throughput screening. Structurally distinct from previously described selective COX-2 inhibitors, these benzopyrans contain a carboxylic acid function…

Effects of a tetramethoxyhydroxyflavone p7f on the expression of inflammatory mediators in LPS-treated human synovial fibroblast and macrophage cells.

J Microbiol Biotechnol. 2008 Apr;18(4):686-94 Authors: Yoon DY, Cho MC, Kim JH, Kim EJ, Kang JW, Seo EH, Shim JH, Kim SH, Lee HG, Oh GT, Hong JT, Park JW, Kim JW The inhibitory effects of 5,6,3′,5′-tetramethoxy 7,4′-hydroxyflavone (labeled as p7F) were elucidated on the productions of proinflammatory cytokines as well as inflammatory mediators in…

Technology insight: adult mesenchymal stem cells for osteoarthritis therapy.

Nat Clin Pract Rheumatol. 2008 Jul;4(7):371-80 Authors: Nöth U, Steinert AF, Tuan RS Despite the high prevalence and morbidity of osteoarthritis (OA), an effective treatment for this disease is currently lacking. Restoration of the diseased articular cartilage in patients with OA is, therefore, a challenge of considerable appeal to researchers and clinicians. Techniques that cause…

Vitamin K and rheumatoid arthritis.

IUBMB Life. 2008 Jun;60(6):355-61 Authors: Okamoto H Vitamin K2 [menaquinone-4 (MK-4)] has been reported to induce apoptosis in hepatocellular carcinoma, leukemia, and MDS cell lines. The effects of MK-4 on the development of arthritis have never been addressed so far. In this study, we investigated the effect of MK-4 upon the proliferation of rheumatoid synovial…

Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN gene transfer.

Arthritis Rheum. 2008 Jun;58(6):1650-6 Authors: Wang CR, Shiau AL, Chen SY, Lin LL, Tai MH, Shieh GS, Lin PR, Yo YT, Lee CH, Kuo SM, Liu MF, Jou IM, Yang CY, Shen PC, Lee HL, Wu CL OBJECTIVE: The phosphatidylinositol 3-kinase (PI 3-kinase)/Akt pathway is known to be activated in rheumatoid arthritis (RA) synovial tissue,…

Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts.

Inflamm Res. 2008 Jun;57(6):260-5 Authors: Lu Y, Wang WJ, Leng JH, Cheng LF, Feng L, Yao HP OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). MATERIALS AND METHODS: RASF were obtained from the synovial tissue of…