Treatment of central nervous system involvement associated with primary Sjögren’s syndrome.

Curr Pharm Des. 2008;14(13):1270-3 Authors: Ozgocmen S, Gur A Sjögren’s syndrome (SS) is a chronic autoimmune disease that mainly affects the exocrine glands and usually presents with sicca symptoms of the main mucosal surfaces. The prevalence and the type of central nervous system (CNS) tissue damage caused by SS are debatable. The wide spectrum of…

Fetal cells of mesenchymal origin in cultures derived from synovial tissue and skin of patients with rheumatoid arthritis.

Joint Bone Spine. 2008 Oct;75(5):563-6 Authors: Hromadnikova I, Zlacka D, Hien Nguyen TT, Sedlackova L, Zejskova L, Sosna A The transplacental cell transfer naturally takes place during pregnancy and occurs bi-directionally between the mother and fetus. Using real-time polymerase chain reaction (PCR) assay and sex determining region Y (SRY) gene as a marker, we examined…

Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.

Biochem Biophys Res Commun. 2008 Aug 22;373(2):181-5 Authors: Imada K, Lin N, Liu C, Lu A, Chen W, Yano M, Sato T, Ito A Aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 have been shown to play crucial roles in cartilage destruction in arthritic diseases, including rheumatoid arthritis and osteoarthritis. In this study,…

Chondrogenic potential of mesenchymal stem cells from patients with rheumatoid arthritis and osteoarthritis: measurements in a microculture system.

Cells Tissues Organs. 2009;189(5):307-16 Authors: Dudics V, Kunstár A, Kovács J, Lakatos T, Géher P, Gömör B, Monostori E, Uher F BACKGROUND: Mesenchymal stem cells (MSCs) have the potential to differentiate into distinct mesenchymal tissues; including cartilage and bone, they can be an attractive cell source for cartilage tissue engineering approaches. Our objective here was…

Parthenolide inhibits proliferation of fibroblast-like synoviocytes in vitro.

Inflammation. 2008 Aug;31(4):281-5 Authors: Parada-Turska J, Mitura A, Brzana W, JabÅ‚oÅ„ski M, Majdan M, Rzeski W Parthenolide is a bioactive constituent of an aromatic herb Feverfew (Tanacetum parthenium). It has been found that both parthenolide and extract of feverfew have anti-inflammatory and antinociceptive properties. Moreover, they demonstrate antiproliferative activities on different human tumour cells. The…

Exercise tolerance in children with juvenile idiopathic arthritis after autologous SCT.

Bone Marrow Transplant. 2008 Sep;42(5):351-6 Authors: Takken T, van den Beuken C, Wulffraat NM, Helders PJ, van der Net J Children with juvenile idiopathic arthritis (JIA) often have significant physical impairment. A minority is unresponsive to combinations of medications, and a possible treatment of resistant JIA is intense immunosuppression followed by autologous hematopoietic SCT (ASCT).…

The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis.

Immunol Rev. 2008 Jun;223:252-70 Authors: Noss EH, Brenner MB SUMMARY: Fibroblast-like synoviocytes (FLS) are resident mesenchymal cells of synovial joints that have been recognized to play an increasingly important role in the pathogenesis of rheumatoid arthritis (RA). Activation of FLS in the setting of RA leads to the production of a broad array of cell…

High-dose chemotherapy followed by autologous CD34+ stem cell transplantation in the treatment of severe refractory multisystem autoimmune diseases of adults–first experiences in Hungary

Orv Hetil. 2008 Jul 27;149(30):1405-12 Authors: Váróczy L, Illés A, Kiss E, Szekanecz Z, Soltész P, Sipka S, Kiss A, Udvardy M, Szegedi G, Zeher M High dose chemotherapy followed by autologous stem cell support is a promising therapeutical approach in the treatment of severe refractory multisystem autoimmune diseases. The aim of this study was…

Fractalkine–a proinflammatory chemokine in rheumatoid arthritis

Z Rheumatol. 2008 Sep;67(5):424-8 Authors: Blaschke S, Müller GA Fractalkine (CX3CL1), so far the only member of the CX3C class of chemokines, and its receptor, CX3CR1, are strongly expressed in the chronically inflamed synovial tissue of patients with rheumatoid arthritis (RA). Due to the specific binding of Fractalkine to its receptor, many proinflammatory reactions involved…