Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.

Arthritis Res Ther. 2010;12(2):R49 Authors: Page CE, Smale S, Carty SM, Amos N, Lauder SN, Goodfellow RM, Richards PJ, Jones SA, Topley N, Williams AS INTRODUCTION: The first few months after symptom onset represents a pathologically distinct phase in rheumatoid arthritis (RA). We used relevant experimental models to define the pathological role of interferon-gamma (IFN-gamma)…

Modulation of the response of rheumatoid arthritis synovial fibroblasts to proinflammatory stimulants with cyclic tensile strain.

Cytokine. 2010 Jul;51(1):35-41 Authors: Bader RA, Wagoner KL Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the…

Autotaxin and lysophospholipids in rheumatoid arthritis.

Curr Opin Investig Drugs. 2010 May;11(5):515-26 Authors: Bourgoin SG, Zhao C Autotaxin (ATX) is an autocrine motility-stimulating factor and an extracellular enzyme that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA). Although ATX can also hydrolyze sphingosylphosphorylcholine (SPC) to sphingosine-1-phosphate (S1P), the major source of extracellular S1P originates from the intracellular phosphorylation of…

Salivary gland stem cells: Can they restore radiation-induced salivary gland dysfunction?]

HNO. 2010 Jun;58(6):556-63 Authors: Rotter N, Schwarz S, Jakob M, Brandau S, Wollenberg B, Lang S Adult stem cells are actively investigated in the fields of regenerative medicine and tissue engineering, as they exhibit specific characteristics that make them promising candidates for cellular therapies. Depending on their tissue of origin these characteristics include long-term proliferation…

Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton.

J Cell Biochem. 2010 Oct 1;111(2):249-57 Authors: Chanda D, Kumar S, Ponnazhagan S Mesenchymal stem cells (MSCs) are the most popular among the adult stem cells in tissue engineering and regenerative medicine. Since their discovery and functional characterization in the late 1960s and early 1970s, MSCs or MSC-like cells have been obtained from various mesodermal…

Autologous stromal vascular fraction cells: a tool for facilitating tolerance in rheumatic disease.

Cell Immunol. 2010;264(1):7-17 Authors: Ichim TE, Harman RJ, Min WP, Minev B, Solano F, Rodriguez JP, Alexandrescu DT, De Necochea-Campion R, Hu X, Marleau AM, Riordan NH Since the days of Medawar, the goal of therapeutic tolerogenesis has been a “Holy Grail” for immunologists. While knowledge of cellular and molecular mechanisms of this process has…

Overlapping juvenile idiopathic arthritis and systemic lupus erythematosus: a case report.

Rheumatol Int. 2010 Jul 30; Authors: Bazsó A, Sevcic K, Orbán I, Poór G, Balogh Z, Kiss E Hereby, we report the case of a 12-year-old girl developing oligoarthritis and progressing into a polyarticular form. Rheumatoid factor was positive, and juvenile idiopathic arthritis (JIA) was diagnosed. After a poor response to DMARDs, an anti-TNF agent…

Mesenchymal stem cells in arthritis: role of bone marrow microenvironment.

Arthritis Res Ther. 2010;12(4):135 Authors: Jorgensen C Based on their capacity to suppress immune responses, multipotent mesenchymal stromal cells (MSCs) are intensively studied for regenerative medicine. Moreover, MSCs are potent immunomodulatory cells that occur through the secretion of soluble mediators including nitric oxide, transforming growth factor beta, and HLAG5. The MSCs, however, are also able…

Does the KIR2DS5 gene protect from some human diseases?

PLoS One. 2010;5(8):e12381 Authors: Nowak I, Majorczyk E, WiÅ›niewski A, Pawlik A, Magott-Procelewska M, Passowicz-MuszyÅ„ska E, Malejczyk J, PÅ‚oski R, Giebel S, Barcz E, ZoÅ„-Giebel A, Malinowski A, Tchórzewski H, Chlebicki A, Łuszczek W, Kurpisz M, GryboÅ› M, WilczyÅ„ski J, Wiland P, Senitzer D, Sun JY, Jankowska R, Klinger M, KuÅ›nierczyk P BACKGROUND: KIR2DS5 gene…

Targeting improves MSC treatment of inflammatory bowel disease.

Mol Ther. 2010 Jul;18(7):1365-72. Epub 2010 Apr 13. Targeting improves MSC treatment of inflammatory bowel disease. Ko IK, Kim BG, Awadallah A, Mikulan J, Lin P, Letterio JJ, Dennis JE. Source Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA. Abstract Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is an…