Current value of stem-cell transplantation in autoimmune diseases

Z Rheumatol. 2008 Dec;67(8):716-22 Authors: Kötter I, Schmalzing M, Henes J, Vogel W, Kanz L Transplantations of autologous or allogeneic stem cells from bone marrow or peripheral blood are preformed for the treatment of resistant autoimmune diseases. Data have been systematically collected since 1996. We describe the historical development of this procedure for autoimmune diseases,…

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.

Arthritis Rheum. 2008 Dec;58(12):3765-75 Authors: Rice JW, Veal JM, Fadden RP, Barabasz AF, Partridge JM, Barta TE, Dubois LG, Huang KH, Mabbett SR, Silinski MA, Steed PM, Hall SE OBJECTIVE: To evaluate the ability of SNX-7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and…

• Telomerase transduced osteoarthritis fibroblast-like synoviocytes display a distinct gene expression profile.

J Rheumatol. 2009 Jan;36(1):141-55 Authors: Sun Y, Mauerhan DR, Firestein GS, Loeffler BJ, Hanley EN, Gruber HE OBJECTIVE: To examine the differential gene expression in telomerase transduced osteoarthritis fibroblast-like synoviocytes (hTERT-OA 13A FLS) and telomerase transduced rheumatoid arthritis FLS (hTERT-RA 516 FLS) and test the hypothesis that longterm culture of hTERT-OA 13A FLS display a…

Toll-like receptor-mediated signaling in human adipose-derived stem cells: implications for immunogenicity and immunosuppressive potential.

Tissue Eng Part A. 2009 Jul;15(7):1579-89 Authors: Lombardo E, DelaRosa O, Mancheño-Corvo P, Menta R, Ramìrez C, Büscher D Human adipose-derived stem cells (hASCs) are mesenchymal stem cells with reduced immunogenicity and the capability to modulate immune responses. These properties make hASCs of special interest as therapeutic agents in the settings of chronic inflammatory and…

Chronic graft-versus-host disease presenting as bullous lesions

Actas Dermosifiliogr. 2008 Dec;99(10):803-7 Authors: del Pozo J, Garcìa-Silva J, Yebra-Pimentel MT Graft-vs-host disease is still the leading cause of morbidity and mortality in patients undergoing bone marrow transplantation. It is important to start treatment early to reduce the severity and consequences of this complication. Cutaneous lesions are often the presenting compliant of graft-vs-host disease…

Case report: a case of pyoderma gangrenosum with intractable leg ulcers treated by allogeneic cultured dermal substitutes.

Dermatol Online J. 2008;14(11):17 Authors: Toyozawa S, Yamamoto Y, Nishide T, Kishioka A, Kanazawa N, Matsumoto Y, Kuroyanagi Y, Furukawa F Pyoderma gangrenosum (PG) is an idiopathic, inflammatory, ulcerative disease of undetermined cause. Both topical and systemic treatments of corticosteroids and cyclosporine are commonly used for the ulcers of PG, but these ulcers are often…

Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models.

Int Immunopharmacol. 2009 Mar;9(3):268-76 Authors: Lee JD, Huh JE, Jeon G, Yang HR, Woo HS, Choi DY, Park DS Rheumatoid arthritis (RA) is an aggressive inflammatory disease in which cytokines/chemokines are thought to recruit leukocytes and induce angiogenesis. The aim of this study is to investigate the effect of flavonol-rich residual layer of hexane fraction…

Current perspectives of autologous stem cell transplantation for severe Juvenile Idiopathic Arthritis.

Autoimmunity. 2008 Dec;41(8):632-8 Authors: Wulffraat NM, van Rooijen EM, Tewarie R, Brinkman D, Prakken B, Kuis W The majority of children with Juvenile Idiopathic Arthritis can nowadays be treated adequately. However despite the use of combinations of antirheumatic drugs, corticosteroids and the newer so called biologicals (blocking the TNF, Interleukin 1 or Interleukin 6 pathways)…

Mesenchymal stromal cells in rheumatoid arthritis: biological properties and clinical applications.

Curr Stem Cell Res Ther. 2009 Jan;4(1):61-9 Authors: Kastrinaki MC, Papadaki HA Mesenchymal stromal cells (MSC) isolated from a variety of adult tissues including the bone marrow (BM), have the capacity to differentiate into different cell types such as bone and cartilage and have therefore attracted scientific interest as potential therapeutic tools for tissue repair.…