Rat adipose tissue-derived stem cells transplantation attenuates cardiac dysfunction post infarction and biopolymers enhance cell retention

PLoS One. 2010 Aug 10;5(8):e12077. Danoviz ME, Nakamuta JS, Marques FL, dos Santos L, Alvarenga EC, dos Santos AA, Antonio EL, Schettert IT, Tucci PJ, Krieger JE. Heart Institute, University of São Paulo Medical School, São Paulo, Brazil. Abstract BACKGROUND: Cardiac cell transplantation is compromised by low cell retention and poor graft viability. Here, the…

Potential application for mesenchymal stem cells in the treatment of cardiovascular diseases

Can J Physiol Pharmacol. 2005 Jul;83(7):529-39. Bunnell BA, Deng W, Robinson CM, Waldron PR, Bivalacqua TJ, Baber SR, Hyman AL, Kadowitz PJ. Department of Pharmacology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA. Abstract Stem cells isolated from various sources have been shown to vary in their differentiation capacity or…

Bone marrow stem cells for the treatment of ischemic heart disease: a clinical trial review

J Cardiovasc Transl Res. 2009 Jun;2(2):202-18. Epub 2009 Mar 17. Fuh E, Brinton TJ. Stanford University School of Medicine, 318 Campus Drive, James Clark Center E-120, Stanford, CA 94305-5428, USA. Abstract Cardiovascular disease continues to represent a significant and growing source of morbidity and mortality despite advances in traditional treatments. As a result, increasing interest…

Cell therapy for heart failure: the need for a new therapeutic strategy

Expert Rev Cardiovasc Ther. 2010 Aug;8(8):1107-26. Povsic TJ, O’Connor CM. Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA. povsi001@mc.duke.edu Abstract Improvements in the treatment of ischemic heart disease have led to a significant growth in the numbers of patients with systolic heart failure secondary to myocardial injury. Current therapies fail to address…

Stem cell therapy for ischemic heart disease

Antioxid Redox Signal. 2010 Dec 15;13(12):1879-97. Epub 2010 Oct 28. Jameel MN, Zhang J. Department of Medicine, University of Minnesota Medical School , Minneapolis, Minnesota 55455, USA. Abstract Stem cell transplantation has emerged as a novel treatment option for ischemic heart disease. Different cell types have been utilized and the recent development of induced pluripotent…

The future of regenerating the myocardium

Curr Opin Cardiol. 2010 Nov;25(6):575-82. Kuraitis D, Suuronen EJ, Sellke FW, Ruel M. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada. Abstract PURPOSE OF REVIEW: Stem cell therapy for cardiac disease may be facing two major problems nowadays: although vasculogenesis likely occurs as a result of cell therapy, its clinical applications…

Intravenous infusion of mesenchymal stem cells enhances regional perfusion and improves ventricular function in a porcine model of myocardial infarction

Basic Res Cardiol. 2008 Nov;103(6):525-36. Epub 2008 Aug 14. Halkos ME, Zhao ZQ, Kerendi F, Wang NP, Jiang R, Schmarkey LS, Martin BJ, Quyyumi AA, Few WL, Kin H, Guyton RA, Vinten-Johansen J. Cardiothoracic Research Laboratory, Division of Cardiothoracic Surgery, Emory Crawford Long Hospital, 550 Peachtree Street, NE, Atlanta, GA 30308, USA. Abstract Transplantation of…

Human bone marrow-derived adult stem cells for post-myocardial infarction cardiac repair: current status and future directions

Singapore Med J. 2009 Oct;50(10):935-42. Wei HM, Wong P, Hsu LF, Shim W. Research and Development Unit, National Heart Centre, 9 Hospital Drive, Blk C, #03-2, Singapore. Abstract Stem cell-based cell therapy has emerged as a potentially therapeutic option for patients with acute myocardial infarction (AMI) and heart failure. With the completion of a number…

Current and future status of stem cell therapy in heart failure

Curr Treat Options Cardiovasc Med. 2010 Dec;12(6):614-27. D’Alessandro DA, Michler RE. Department of Cardiovascular and Thoracic Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, 3400 Bainbridge Avenue, New York, NY, 10467, USA. Abstract OPINION STATEMENT: As heart transplantation and mechanical assist technology are inadequate solutions for the growing clinical epidemic of heart failure, myocardial regeneration…