A two-year follow-up study of co-transplantation with neural stem/precursor cells and mesenchymal stromal cells in ischemic stroke patients.

Stem cell therapy is an emerging therapeutic modality in the treatment of stroke. We assessed the safety and feasibility of the co-transplantation of neural stem/precursor cells (NSPCs) and mesenchymal stromal cells (MSCs) in patients with ischemic stroke. Eight patients were enrolled in this study. All patients had a hemisphere with infarct lesions located on one…

Neurogenic differentiation of murine and human adipose-derived stromal cells.

Neurogenic differentiation of murine and human adipose-derived stromal cells. Safford KM1, Hicok KC, Safford SD, Halvorsen YD, Wilkison WO, Gimble JM, Rice HE. Author information Abstract The identification of cells capable of neuronal differentiation has great potential for cellular therapies. We examined whether murine and human adipose-derived adult stem (ADAS) cells can be induced to…

Cell-replacement therapy with stem cells in neurodegenerative diseases.

Curr Neurovasc Res. 2004 Jul;1(3):283-9. Cell-replacement therapy with stem cells in neurodegenerative diseases. Silani V, Corbo M. Department of Neurology and Laboratory of Neuroscience – Dino Ferrari Center, University of Milan Medical School – IRCCS Istituto Auxologico Italiano. vincenzo@silani.com Abstract In the past few years, research on stem cells has expanded greatly as a tool…

Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment.

Expert Rev Mol Med. 2006 May 24;8(11):1-22. Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment. Goodall EF, Morrison KE. Division of Neurosciences, University of Birmingham, Edgbaston, Birmingham, B152TT, UK. efg355@bham.ac.uk Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by loss of motor neurons. The cause of disease is…

Cellular therapies in motor neuron diseases.

Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1128-38. Epub 2006 Jun 17. Cellular therapies in motor neuron diseases. Nayak MS, Kim YS, Goldman M, Keirstead HS, Kerr DA. Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Abstract Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are prototypical motor…

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis.

Neurobiol Dis. 2008 Sep;31(3):395-405. Epub 2008 Jun 4. Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. Vercelli A, Mereuta OM, Garbossa D, Muraca G, Mareschi K, Rustichelli D, Ferrero I, Mazzini L, Madon E, Fagioli F. Department of Anatomy, Pharmacology and Forensic Medicine,…

Amyotrophic lateral sclerosis: clinical management and research update.

Curr Neurol Neurosci Rep. 2009 Jan;9(1):59-68. Amyotrophic lateral sclerosis: clinical management and research update. Andrews J. The Neurological Institute of New York, 710 West 168th Street, New York, NY 10032, USA. ja2289@columbia.edu Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that selectively affects the motor neurons of the brain and spinal cord. ALS…

Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery.

Growth Factors. 2009 Jun;27(3):133-40. Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery. Lunn JS, Hefferan MP, Marsala M, Feldman EL. Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, USA. Abstract Amyotrophic lateral sclerosis (ALS) is characterized by loss of both upper and lower motor neurons. ALS progression…

Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice.

Gene Ther. 2009 Oct;16(10):1234-44. Epub 2009 Jul 23. Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Hwang DH, Lee HJ, Park IH, Seok JI, Kim BG, Joo IS, Kim SU. Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea.…