Stem cell-based cell therapy in neurological diseases: a review.

2009 Aug 1;87(10):2183-200. Stem cell-based cell therapy in neurological diseases: a review. Kim SU, de Vellis J. Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada. sukim@interchange.ubc.ca Abstract Human neurological disorders such as Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, multiple sclerosis (MS), stroke, and…

Regeneration and repair in multiple sclerosis: the role of cell transplantation.

2009 Jun 12; 456(3) : 101-6. Epub 2009 Jan 17. Regeneration and repair in multiple sclerosis: the role of cell transplantation. Pluchino S, Zanotti L, Brini E, Ferrari S, Martino G. Neuroimmunology Unit and Institute of Experimental Neurology (INSpe), DIBIT-San Raffaele Scientific Institute, via Olgettina 58, 20123 Milano, Italy. Abstract Physiological (spontaneous) and reactive (reparative)…

Multiple sclerosis: Hematopoietic stem cell transplantation: hope and hype.

2009 Jun;5(6):300-2 Multiple sclerosis: Hematopoietic stem cell transplantation: hope and hype. Stangel M Abstract A trial of autologous hematopoietic stem cell transplantation to treat multiple sclerosis has yielded promising results, generating considerable interest within both the clinical literature and the mainstream press.the findings should, however, be interpreted with some caution, and larger, randomized trials will…

Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies.

2008 Dec; 2(4) : 699-705 Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies. Greco SJ, Rameshwar P Abstract The therapeutic utilization of stem cells has been ongoing for several decades, principally in the form of bone marrow (BM) transplants to treat various hematological disorders and other immune-related diseases. More recently,…

The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience.

2008 Nov; 110(9) : 889-96. Epub 2008 Mar 28. The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience. Karussis D, Kassis I. Department of Neurology, Laboratory of Neuroimmunology, Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Hospital, Ein-Karem, Jerusalem, Israel. karus@cc.huji.ac.il Abstract The reported neurodegeneration process in multiple sclerosis may explain…

NeHuman neural stem cells genetically modified for brain repair in neurological disorders.

2004 Sep; 24(3) : 159-71. Human neural stem cells genetically modified for brain repair in neurological disorders. Kim SU. Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea. sukim@ajou.ac.kr Abstract Existence of multipotent neural stem cells (NSC) has been known in developing or adult mammalian CNS, including humans. NSC have the capacity to…

Splice modification to restore functional dystrophin synthesis in Duchenne muscular dystrophy.

2010;16(8):988-1001 Splice modification to restore functional dystrophin synthesis in Duchenne muscular dystrophy. Wilton SD, Fletcher S Abstract In little more than a decade, induced exon skipping as a therapy to treat Duchenne muscular dystrophy (DMD) has progressed from a concept tested in vitro, to pre-clinical evaluation in mouse and dog models, and recent completion of…

Microdystrophin Delivery in Dystrophin-Deficient (mdx) Mice by Genetically-Corrected Syngeneic MSCs Transplantation.

2010 Sep; 42(7) : 2731-9 Microdystrophin Delivery in Dystrophin-Deficient (mdx) Mice by Genetically-Corrected Syngeneic MSCs Transplantation. Xiong F, Xu Y, Zheng H, Lu X, Feng S, Shang Y, Li Y, Zhang Y, Jin S, Zhang C Abstract Cell transplantation and gene therapy are two promising therapeutical approaches for the treatment on Duchenne Muscular Dystrophy (DMD).…