Critical questions for preclinical trials on safety and efficacy of vascular endothelial growth factor-based therapeutic angiogenesis for ischemic stroke.

CNS Neurol Disord Drug Targets. 2011 Mar;10(2):215-34. Critical questions for preclinical trials on safety and efficacy of vascular endothelial growth factor-based therapeutic angiogenesis for ischemic stroke. Manoonkitiwongsa PS. Source Neural Engineering Program, Huntington Medical Research Institutes, Pasadena, CA, USA. stevemanoon@hotmail.com Abstract Therapeutic angiogenesis is a novel treatment for ischemic stroke, and vascular endothelial growth factor…

Progress and prospects: stem cells and neurological diseases.

Gene Ther. 2011 Jan;18(1):1-6. Epub 2010 Sep 30. Progress and prospects: stem cells and neurological diseases. Gögel S, Gubernator M, Minger SL. Source Wolfson Centre for Age-Related Diseases, Guy’s Campus, King’s College London, London, UK. stefanie.gogel@kcl.ac.uk Abstract The central nervous system has limited capacity of regenerating lost tissue in slowly progressive, degenerative neurological conditions such…

Vascular protection and restorative therapy in ischemic stroke.

Cell Transplant. 2011;20(1):95-7. Epub 2010 Sep 30. Vascular protection and restorative therapy in ischemic stroke. Yamashita T, Deguchi K, Nagotani S, Abe K. Source Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Abstract Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring…

Parkinson’s disease and stem cells.

2011 Jan; 1812(1) : 1-11. Epub 2010 Aug 14. Stem cell potential in Parkinson’s disease and molecular factors for the generation of dopamine neurons. Kim HJ. Abstract Parkinson’s disease (PD) involves the loss of dopamine (DA) neurons, making it the most expected neurodegenerative disease to be treated by cell replacement therapy. Stem cells are a…

Implications for cell based therapies in Parkinson’s.

Biol Blood Marrow Transplant. 2010 Nov; 16(11) : 1530-40. Epub 2010 Jun 10. Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: implications for cellbased therapies in Parkinson’s disease. Somoza R, Juri C, Baes M, Wyneken U, Rubio FJ. Institute of Science, Clinica Alemana Universidad del Desarrollo, Santiago, Chile. Abstract It is thought that…

Ageing and neurodegenerative diseases.

Ageing Res Rev. 2010 Nov; 9 Suppl 1 : S36-46. Epub 2010 Aug 21. Ageing and neurodegenerative diseases. Hung CW, Chen YC, Hsieh WL, Chiou SH, Kao CL. Department of Neurology, Zhongxiao Branch, Taipei City Hospital/No 87, Tongde Rd, Nangang Dist, Taipei City 115, Taiwan. Abstract Ageing, which all creatures must encounter, is a challenge…