Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy: A Randomized, Double-Blind, Controlled Study.

Vangeness article   J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.00058. Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy: A Randomized, Double-Blind, Controlled Study. Vangsness CT Jr1, Farr J 2nd2, Boyd J3, Dellaero DT4, Mills CR5, Leroux-Williams M5. Author information 1University of Southern California Orthopaedic…

Application of biologics in the treatment of the rotator cuff, meniscus, cartilage, and osteoarthritis.

  J Am Acad Orthop Surg. 2014 Feb;22(2):68-79. doi: 10.5435/JAAOS-22-02-68. Application of biologics in the treatment of the rotator cuff, meniscus, cartilage, and osteoarthritis. Anz AW, Hackel JG, Nilssen EC, Andrews JR. Abstract Advances in our knowledge of cell signaling and biology have led to the development of products that may guide the healing/regenerative process.…

Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints.

BMC Musculoskelet Disord. 2013 Dec 1;14:337. doi: 10.1186/1471-2474-14-337. Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints. Pak J, Chang JJ, Lee JH, Lee SH. Author information Abstract BACKGROUND: Adipose tissue-derived stem cells (ADSCs), a type of mesenchymal stem cells (MSCs), have great potential as therapeutic agents in regenerative medicine. Numerous…

Cell Surgical Network Study for Stromal Vascular Fraction Registered by ClinicalTrials.gov

Rancho Mirage, CA (PRWEB) October 14, 2013 Clinicaltrials.gov, a service of the U.S. National Institutes of Health has registered on their public site an IRB approved safety study from the Cell Surgical Network, Inc.. This study is available for patients with various degenerative and inflammatory conditions to undergo Stromal Vascular Fraction deployment for the evaluation and for the…

Ossification of the Posterior Longitudinal Ligament of the Lumbar Spine: A Case Series.

Neurosurgery. 2010 Sep 23; Authors: Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y BACKGROUND:: Reports on ossification of the posterior longitudinal ligament (OPLL) of the lumbar spine have so far been limited. OBJECTIVE:: To evaluate surgically documented cases of lumbar OPLL at our facility to clarify its characteristics and analyze clinical…

Recent advances in disc cell biology.

Spine (Phila Pa 1976). 2003 Jan 15;28(2):186-93 Authors: Gruber HE, Hanley EN STUDY DESIGN: There have been many advances over the past decade in understanding and experimentally modulating biologic aspects of intervertebral disc cell function. An overview of the current state of this biologic research is presented. OBJECTIVES: To provide clinicians with a review of…

Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration.

Biomaterials. 2003 Sep;24(20):3531-41 Authors: Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T Intervertebral disc degeneration is considered to be one of the major causes of low back pain. Despite this irreversible phenomenon, attempts to decelerate disc degeneration using various techniques have been reported. However, to…

Biologic strategies for the therapy of intervertebral disc degeneration.

Expert Opin Biol Ther. 2003 Dec;3(8):1209-14 Authors: Gruber HE, Hanley EN Recent advances in tissue engineering have led to promising new approaches for the biologic treatment of disc degeneration. At present, there is no effective therapy for disc degeneration, a condition which results in large healthcare and socio-economic costs. This article will examine the current…

Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells.

Gene Ther. 2004 Jan;11(1):34-41 Authors: Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O’Keefe RJ, Schwarz EM Deficiencies in skeletal tissue repair and regeneration lead to conditions like osteoarthritis, osteoporosis and degenerative disc disease. While no cure for these conditions is available, the use of human bone marrow derived-mesenchymal stem cells (HuMSCs) has been shown…