Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy: A Randomized, Double-Blind, Controlled Study.

Vangeness article   J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.00058. Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy: A Randomized, Double-Blind, Controlled Study. Vangsness CT Jr1, Farr J 2nd2, Boyd J3, Dellaero DT4, Mills CR5, Leroux-Williams M5. Author information 1University of Southern California Orthopaedic…

Application of biologics in the treatment of the rotator cuff, meniscus, cartilage, and osteoarthritis.

  J Am Acad Orthop Surg. 2014 Feb;22(2):68-79. doi: 10.5435/JAAOS-22-02-68. Application of biologics in the treatment of the rotator cuff, meniscus, cartilage, and osteoarthritis. Anz AW, Hackel JG, Nilssen EC, Andrews JR. Abstract Advances in our knowledge of cell signaling and biology have led to the development of products that may guide the healing/regenerative process.…

Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints.

BMC Musculoskelet Disord. 2013 Dec 1;14:337. doi: 10.1186/1471-2474-14-337. Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints. Pak J, Chang JJ, Lee JH, Lee SH. Author information Abstract BACKGROUND: Adipose tissue-derived stem cells (ADSCs), a type of mesenchymal stem cells (MSCs), have great potential as therapeutic agents in regenerative medicine. Numerous…

Orthopedics: bone substitutes and beyond.

Orthopedics. 2010 Sep 7; 33(9) : 661. doi: 10.3928/01477447-20100722-31. Allograft alternatives: bone substitutes and beyond. Goodman SB. Abstract Excessive wear debris, deep infection, periprosthetic fracture, and other causes can lead to bone loss associated with total joint replacements. When performing revisions, surgeons are often preoccupied by the failed implant and the method of replacement, and…

Cartilage regeneration by bone marrow cells-seeded scaffolds.

Cartilage regeneration by bone marrow cells-seeded scaffolds. Wegener B, Schrimpf FM, Bergschmidt P, Pietschmann MF, Utzschneider S, Milz S, Jansson V, Müller PE. Abstract Different approaches exist for the treatment of small articular cartilage defects. Several studies show comparable results for autologous chondrocyte implantation (ACI) and microfracture. Unfortunately, the fibrocartilage resulting from microfracture has neither…