Modern aspects of pathophysiology and prevention of erectile dysfunction and cavernous fibrosis after radical prostatectomy.

Urologiia. 2009 Mar-Apr;(2):46-51 Modern aspects of pathophysiology and prevention of erectile dysfunction and cavernous fibrosis after radical prostatectomy. Veliev EI, Vanin AF, Kotov SV, Shiahlo VK. Abstract Partial denervation of cavernous tissue (CT) during nerve sparing radical prostatectomy (RPE) can cause development of neuropraxy and cavernous fibrosis (CF) resulting in erectile dysfunction (ED) after operation.…

A review of current progress in gene and stem cell therapy for erectile dysfunction.

Expert Opin Biol Ther. 2008 Oct;8(10):1521-38 A review of current progress in gene and stem cell therapy for erectile dysfunction. Gur S, Kadowitz PJ, Hellstrom WJ: Abstract   BACKGROUND: Current gene-based strategies for treatment of erectile dysfunction (ED) are based on the nitric oxide (NO)/cGMP system; although growth factors, calcium sensitization, and potassium channel expression…

Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction.

BJU Int. 2008 Jul;102(2):220-4; discussion 224. Epub 2008 Jul 1. Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction. Song YS, Lee HJ, Park IH, Lim IS, Ku JH, Kim SU OBJECTIVE: To investigate the feasibility of applying neural crest stem cells (NCSCs), with multipotent capacity, to repair injury…

Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat.

BJU Int. 2008 May;101(9):1156-64. Epub 2008 Feb 21. Gonzalez-Cadavid NF: Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, OBJECTIVE: To determine whether skeletal muscle-derived stem cells (MDSCs)…

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction.

Asian J Androl. 2008 Jan;10(1):14-22. Endothelium-specific gene and stem cell-based therapy for erectile dysfunction. Strong TD, Gebska MA, Burnett AL, Champion HC, Bivalacqua TJ. Abstract Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken…

Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury.

Asian J Androl. 2008 Jan;10(1):54-9 Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury. Bella AJ, Lin G, Cagiannos I, Lue TF. Abstract Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective…

Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radical prostatectomy.

Adv Urol. 2008:594868 Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radical prostatectomy. Albersen M, Joniau S, Claes H, Van Poppel H Abstract Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which…