A review of the potential to restore vision with stem cells.

Mooney I, LaMotte J. Source Southern California College of Optometry, Fullerton, California 92831, USA. Abstract Vision research involving stem cells is a rapidly evolving field. Animal experiments have shown that in response to environmental cues, stem cells can repopulate damaged retinas, regrow neuronal axons, repair higher cortical pathways, and restore pupil reflexes, light responses and basic…

Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve.

Dahlmann-Noor A, Vijay S, Jayaram H, Limb A, Khaw PT. Source UCL Partners AHSC, London, United Kingdom. Abstract The 3 most common causes of visual impairment and legal blindness in developed countries (age-related macular degeneration, glaucoma, and diabetic retinopathy) share 1 end point: the loss of neural cells of the eye. Although recent treatment advances can slow down the progression of…

Stem cell-based therapeutic applications in retinal degenerative diseases.

Huang Y, Enzmann V, Ildstad ST. Source Institute for Cellular Therapeutics, University of Louisville, 570 S. Preston Street, Suite 404, Louisville, KY 40202-1760, USA. Abstract Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinaldegeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration (AMD), diabetic retinopathy, cataracts, and glaucoma.…

Retinal incorporation and differentiation of mesenchymal stem cells intravitreally injected in the injured retina of rats.

Castanheira P, Torquetti L, Nehemy MB, Goes AM. Source Department of Biochemistry, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Abstract PURPOSE: To evaluate the pattern of retinal integration and differentiation of mesenchymal stem cells (MSCs) injected into the vitreous cavity of rat eyes with retinal injury. METHODS: Adult rat retinas…

Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection.

Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S. Source Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Hashomer, Israel. hani.verbin@sheba.health.gov.il Abstract PURPOSE: To evaluate the neuroprotective effect of intravitreal injections of neurotrophic factors secreting mesenchymal stem cells (NTF-SCs) on the survival of…

Intravitreal autologous bone marrow-derived mononuclear cell transplantation: a feasibility report.

Jonas JB, Witzens-Harig M, Arseniev L, Ho AD. Source Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University, Heidelberg, Germany. Jost.Jonas@augen.ma.uni-heidelberg.de Abstract PURPOSE: To report on the feasibility and safety of an intravitreal injection of mononuclear cells derived from autologous bone marrow. METHODS: A 43-year-old patient with very advanced atrophy of the retina and optic nerve caused…

Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells.

Otani A, Dorrell MI, Kinder K, Moreno SK, Nusinowitz S, Banin E, Heckenlively J, Friedlander M. Source Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA. Abstract Inherited retinal degenerations afflict 1 in 3,500 individuals and are a heterogeneous group of diseases that result in profound vision loss, usually the result…

Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes.

Zhang J, Wu Y, Jin Y, Ji F, Sinclair SH, Luo Y, Xu G, Lu L, Dai W, Yanoff M, Li W, Xu GT. Source Laboratory of Clinical Visual Sciences, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China. Abstract PURPOSE:…

Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma.

Johnson TV, Bull ND, Hunt DP, Marina N, Tomarev SI, Martin KR. Source Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom. Abstract Purpose. Retrograde neurotrophic factor transport blockade has been implicated in the pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some neurodegenerative conditions in the brain and spinal cord, in part…

Use of Adipose-Derived Mesenchymal Stem Cells in Keratoconjunctivitis Sicca in a Canine Model

Keratoconjunctivitis sicca (KCS) or dry eye disease (DED) is an immune-mediated multifactorial disease, with high level of prevalence in humans and dogs. Our aim in this study was to investigate the therapeutic effects of allogeneic adipose-derived mesenchymal stromal cells (Ad-MSCs) implanted around the lacrimal glands in 12 dogs (24 eyes) with KCS, which is refractory…