Visual Observations of an American Patient With Leber Hereditary Optic Neuropathy After Purported Injections of Stem Cells in China

We describe our clinical observations of a patient with Leber hereditary optic neuropathy and acute vision loss. She received what she was told were umbilical cord blood stem cells by a clinic in Qingdao, China. A 42-year-old woman noted vision loss in August 2009. Visual acuity was 20/80 (55 Early Treatment Diabetic Retinopathy Study [ETDRS]…

Regenerative Therapeutic Potential of Adipose Stromal Cells in Early Stage Diabetic Retinopathy

Abstract Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Early stage DR involves inflammation, vascular leakage, apoptosis of vascular cells and neurodegeneration. In this study, we hypothesized that cells derived from the stromal fraction of adipose tissue (ASC) could therapeutically rescue early stage DR features. Streptozotocin (STZ) induced diabetic athymic nude…

A two-year follow-up study of co-transplantation with neural stem/precursor cells and mesenchymal stromal cells in ischemic stroke patients.

Stem cell therapy is an emerging therapeutic modality in the treatment of stroke. We assessed the safety and feasibility of the co-transplantation of neural stem/precursor cells (NSPCs) and mesenchymal stromal cells (MSCs) in patients with ischemic stroke. Eight patients were enrolled in this study. All patients had a hemisphere with infarct lesions located on one…

Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial

Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial Chris Hyunchul Jo1, Young Gil Lee1, Won Hyoung Shin1, Hyang Kim1, Jee Won Chai2, Eui Cheol Jeong3, Ji Eun Kim4, Hackjoon Shim5, Ji Sun Shin1, Il Seob Shin6, Jeong Chan Ra6, Sohee Oh7, and Kang Sup Yoon1* 1Department of Orthopedic Surgery,…

Neurogenic differentiation of murine and human adipose-derived stromal cells.

Neurogenic differentiation of murine and human adipose-derived stromal cells. Safford KM1, Hicok KC, Safford SD, Halvorsen YD, Wilkison WO, Gimble JM, Rice HE. Author information Abstract The identification of cells capable of neuronal differentiation has great potential for cellular therapies. We examined whether murine and human adipose-derived adult stem (ADAS) cells can be induced to…

Differences between adipose-derived stem cells and mesenchymal stem cells in differentiation into cardiomyocytes

Sheng Li Xue Bao. 2008 Jun 25;60(3):341-7. Differences between adipose-derived stem cells and mesenchymal stem cells in differentiation into cardiomyocytes. [Article in Chinese] Zhang DZ1, Gai LY, Liu HW. Author information: 1Department of Congenital Heart Disease, the General Hospital of Shenyang Military Region, Shenyang 110016, China. Abstract Adipose-derived stem cells (ASCs) are similar to bone…

Cell-replacement therapy with stem cells in neurodegenerative diseases.

Curr Neurovasc Res. 2004 Jul;1(3):283-9. Cell-replacement therapy with stem cells in neurodegenerative diseases. Silani V, Corbo M. Department of Neurology and Laboratory of Neuroscience – Dino Ferrari Center, University of Milan Medical School – IRCCS Istituto Auxologico Italiano. vincenzo@silani.com Abstract In the past few years, research on stem cells has expanded greatly as a tool…

Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment.

Expert Rev Mol Med. 2006 May 24;8(11):1-22. Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment. Goodall EF, Morrison KE. Division of Neurosciences, University of Birmingham, Edgbaston, Birmingham, B152TT, UK. efg355@bham.ac.uk Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by loss of motor neurons. The cause of disease is…

Cellular therapies in motor neuron diseases.

Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1128-38. Epub 2006 Jun 17. Cellular therapies in motor neuron diseases. Nayak MS, Kim YS, Goldman M, Keirstead HS, Kerr DA. Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Abstract Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are prototypical motor…