Cell based therapy for COPD

[Article in Japanese] Kubo H. Source Department of Geriatrics and Gerontology, Tohoku University Hospital. Abstract To develop a new cell based therapy for chronic obstructive pulmonary disease (COPD), we need to understand 1) the role of tissue-specific and bone marrow-derived stem cells, 2) extracellular matrix, and 3) growth factors. Recently, bronchioalveolar stem cells were identified…

Ossification of the Posterior Longitudinal Ligament of the Lumbar Spine: A Case Series.

Neurosurgery. 2010 Sep 23; Authors: Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y BACKGROUND:: Reports on ossification of the posterior longitudinal ligament (OPLL) of the lumbar spine have so far been limited. OBJECTIVE:: To evaluate surgically documented cases of lumbar OPLL at our facility to clarify its characteristics and analyze clinical…

Recent advances in disc cell biology.

Spine (Phila Pa 1976). 2003 Jan 15;28(2):186-93 Authors: Gruber HE, Hanley EN STUDY DESIGN: There have been many advances over the past decade in understanding and experimentally modulating biologic aspects of intervertebral disc cell function. An overview of the current state of this biologic research is presented. OBJECTIVES: To provide clinicians with a review of…

Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration.

Biomaterials. 2003 Sep;24(20):3531-41 Authors: Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, Nakai T, Ando K, Hotta T Intervertebral disc degeneration is considered to be one of the major causes of low back pain. Despite this irreversible phenomenon, attempts to decelerate disc degeneration using various techniques have been reported. However, to…

Biologic strategies for the therapy of intervertebral disc degeneration.

Expert Opin Biol Ther. 2003 Dec;3(8):1209-14 Authors: Gruber HE, Hanley EN Recent advances in tissue engineering have led to promising new approaches for the biologic treatment of disc degeneration. At present, there is no effective therapy for disc degeneration, a condition which results in large healthcare and socio-economic costs. This article will examine the current…

Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells.

Gene Ther. 2004 Jan;11(1):34-41 Authors: Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O’Keefe RJ, Schwarz EM Deficiencies in skeletal tissue repair and regeneration lead to conditions like osteoarthritis, osteoporosis and degenerative disc disease. While no cure for these conditions is available, the use of human bone marrow derived-mesenchymal stem cells (HuMSCs) has been shown…