Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans.

Clin Orthop Relat Res. 2005 Jan;(430):219-26 Authors: Zhang YG, Guo X, Xu P, Kang LL, Li J We sought to determine whether transplanted allogeneic bone mesenchymal stem cells can survive and increase the amount of proteoglycans in intervertebral discs. We used the rabbit intervertebral disc as a model, creating three groups: an uninjected control group,…

New strategies for disc repair: novel preclinical trials.

J Orthop Sci. 2005;10(1):112-8 Authors: Mochida J Degeneration of lumbar intervertebral discs is a major cause of low back complaints, an irreversible occurrence with no currently available treatment. Furthermore, various surgical procedures can accelerate disc degeneration. On the other hand, recent experimental studies on disc cells have demonstrated an important role for the nucleus pulposus…

Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc.

Biomaterials. 2006 Jan;27(3):335-45 Authors: Sakai D, Mochida J, Iwashina T, Hiyama A, Omi H, Imai M, Nakai T, Ando K, Hotta T Intervertebral disc (IVD) degeneration, a common cause of low back pain in humans, is a relentlessly progressive phenomenon with no currently available effective treatment. In an attempt to solve this dilemma, we transplanted…

Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration.

Spine (Phila Pa 1976). 2005 Nov 1;30(21):2379-87 Authors: Sakai D, Mochida J, Iwashina T, Watanabe T, Nakai T, Ando K, Hotta T STUDY DESIGN: An in vivo study to assess the differentiation status of mesenchymal stem cells (MSCs) transplanted to the nucleus pulposus of degenerative discs in a rabbit model. OBJECTIVES: To evaluate the fate…

Cell-based therapy for disc repair.

Spine J. 2005 Nov-Dec;5(6 Suppl):297S-303S Authors: Anderson DG, Risbud MV, Shapiro IM, Vaccaro AR, Albert TJ BACKGROUND CONTEXT: One of the most promising therapies for symptomatic disc degeneration involves the implantation of therapeutic cells into the degenerative disc. PURPOSE: In this article, the rationale and approaches for cell-based tissue engineering of the intervertebral disc are…

Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction.

Eur Spine J. 2006 Aug;15 Suppl 3:S406-13 Authors: Leung VY, Chan D, Cheung KM Over the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect…

Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis.

Spine (Phila Pa 1976). 2006 Aug 15;31(18):2036-42 Authors: Le Visage C, Kim SW, Tateno K, Sieber AN, Kostuik JP, Leong KW STUDY DESIGN: To evaluate the in vitro interactions between human mesenchymal stem cells (MSCs) and degenerative disc cells. OBJECTIVES: To demonstrate the potential of MSCs in regulating the extracellular matrix synthesis of degenerative disc…

Biological treatment strategies for disc degeneration: potentials and shortcomings.

Eur Spine J. 2007 Apr;16(4):447-68 Authors: Paesold G, Nerlich AG, Boos N Recent advances in molecular biology, cell biology and material sciences have opened a new emerging field of techniques for the treatment of musculoskeletal disorders. These new treatment modalities aim for biological repair of the affected tissues by introducing cell-based tissue replacements, genetic modifications…