Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies.

Histol Histopathol. 2007 Sep;22(9):1033-41 Authors: Richardson SM, Mobasheri A, Freemont AJ, Hoyland JA Degeneration of the intervertebral disc (IVD) is a major cause of low back pain affecting a large percentage of the population at some point in their lives. Consequently IVD degeneration and its associated low back pain has a huge socio-economic impact and…

Advances of mesenchymal stem cells transplantation for treating intervertebral disc degeneration

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 May;21(5):502-6 Authors: Liang T, Liu H OBJECTIVE: To introduce the research of mesenchymal stem cells(MSCs) transplantation for treating intervertebral disc degeneration. METHODS: The recent original articles about the MSCs transplantation for treating intervertebral disc degeneration were extensively reviewed. RESULTS: Transplanted MSCs in intervertebral disc can…

In vitro interaction between muscle-derived stem cells and nucleus pulposus cells.

Spine J. 2008 Sep-Oct;8(5):804-9 Authors: Vadalà G, Sobajima S, Lee JY, Huard J, Denaro V, Kang JD, Gilbertson LG BACKGROUND CONTEXT: Current therapies for intervertebral disc degeneration (IDD) are aimed at treating the clinical symptoms arising from IDD rather than directly treating the underlying problem. Pathophysiology of IDD is characterized by a progressive decrease in…

Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future.

J Cell Mol Med. 2008 Dec;12(6A):2205-16 Authors: Hoogendoorn RJ, Lu ZF, Kroeze RJ, Bank RA, Wuisman PI, Helder MN New regenerative treatment strategies are being developed for intervertebral disc degeneration of which the implantation of various cell types is promising. All cell types used so far require in vitro expansion prior to clinical use, as…

Stem cell-mediated regeneration of the intervertebral disc: cellular and molecular challenge.

Neurosurg Focus. 2008;24(3-4):E21 Authors: Jandial R, Aryan HE, Park J, Taylor WT, Snyder EY Regenerative medicine and stem cells hold great promise for intervertebral disc (IVD) disease. The therapeutic implications of utilizing stem cells to repair degenerated discs and treat back pain are highly anticipated by both the clinical and scientific communities. Although the avascular…

Coculture of bone marrow mesenchymal stem cells and nucleus pulposus cells modulate gene expression profile without cell fusion.

Spine (Phila Pa 1976). 2008 Apr 15;33(8):870-6 Authors: Vadalà G, Studer RK, Sowa G, Spiezia F, Iucu C, Denaro V, Gilbertson LG, Kang JD STUDY DESIGN: Changes in gene expression profile and cell fusion of mesenchymal stem cells (MSC) and nucleus pulposus cells (NPC) after coculture were analyzed. OBJECTIVE: To investigate the mechanisms of the…

Stem cell regeneration of degenerated intervertebral discs: current status.

Curr Pain Headache Rep. 2008 Apr;12(2):83-8 Authors: Richardson SM, Hoyland JA Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there…

Disc regeneration: a glimpse of the future.

Clin Neurosurg. 2007;54:122-8 Authors: Tow BP, Hsu WK, Wang JC The normal IVD clinically acts to support and dissipate loads while permitting multiaxial motions of the spine. Its demanding mechanical function is provided by a well-defined microstructural organization and biochemical composition. IVD degeneration is a complex process that disrupts this well-defined organization and biochemical balance.…