Disc regeneration: a glimpse of the future.

Clin Neurosurg. 2007;54:122-8 Authors: Tow BP, Hsu WK, Wang JC The normal IVD clinically acts to support and dissipate loads while permitting multiaxial motions of the spine. Its demanding mechanical function is provided by a well-defined microstructural organization and biochemical composition. IVD degeneration is a complex process that disrupts this well-defined organization and biochemical balance.…

Magnetic resonance imaging of iron oxide labelled stem cells: applications to tissue engineering based regeneration of the intervertebral disc.

Eur Cell Mater. 2008;16:17-25 Authors: Saldanha KJ, Piper SL, Ainslie KM, Kim HT, Majumdar S Minimally-invasive monitoring of regeneration in diseased tissue is an important aspect of stem cell therapy. Magnetic resonance imaging (MRI) based tracking of cells labelled with ferumoxides has the potential for non-invasive in vivo detection and longitudinal assessment of implanted cells.…

Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix.

Arthritis Res Ther. 2008;10(4):R89 Authors: Tapp H, Deepe R, Ingram JA, Kuremsky M, Hanley EN, Gruber HE INTRODUCTION: Adult mesenchymal stem cell therapy has a potential application in the biological treatment of disc degeneration. Our objectives were: to direct adipose-derived mesenchymal stem cells (AD-MSC) from the sand rat to produce a proteoglycan and collagen type…

Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.

Am J Phys Med Rehabil. 2008 Sep;87(9):694-702 Authors: Zhang Y, An HS, Tannoury C, Thonar EJ, Freedman MK, Anderson DG Spine care is a fast-growing sector of the outpatient practice for physiatrists. Current nonsurgical treatment modalities and surgical options for severe symptomatic intervertebral disc degeneration have limited and inconsistent clinical results. Thus, the development of…

Clinical study of lumbar fusion by hybrid construct of stem cells technique and biodegradable material

Zhonghua Wai Ke Za Zhi. 2008 Apr 1;46(7):493-6 Authors: Zhang P, Gan YK, Tang J, Hao YQ, Wang Y, Sun YH, Zhu ZA, Dai KR OBJECTIVE: To explorer the effectiveness of enriched bone marrow stem cells technique for lumbar fusion. METHODS: With the randomization and control principles, 2 graft materials [Enrichment bone marrow mesenchymal stem…

Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model.

Spine (Phila Pa 1976). 2009 Jan 15;34(2):141-8 Authors: Henriksson HB, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A, Brisby H STUDY DESIGN: Experimental and descriptive study of a xenotransplantation model in minipigs. OBJECTIVE: To study survival and function of human mesenchymal stem cells (hMSCs) after transplantation into injured porcine spinal discs, as a…