An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.

Arthritis Res Ther. 2009;11(1):R20 Authors: Le Maitre CL, Baird P, Freemont AJ, Hoyland JA INTRODUCTION: The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for…

Expression and role of connective tissue growth factor in painful disc fibrosis and degeneration.

Spine (Phila Pa 1976). 2009 Mar 1;34(5):E178-82 Authors: Peng B, Chen J, Kuang Z, Li D, Pang X, Zhang X STUDY DESIGN: We collected the specimens of lumbar intervertebral discs from patients with discogenic low back pain, to study the histopathological features and connective tissue growth factor (CTGF) expressions. OBJECTIVE: To study the expression and…

Olfactory stem cells can be induced to express chondrogenic phenotype in a rat intervertebral disc injury model.

Spine J. 2009 Jul;9(7):585-94 Authors: Murrell W, Sanford E, Anderberg L, Cavanagh B, Mackay-Sim A BACKGROUND: In humans, lower back pain is one of the most common causes of morbidity. Many studies implicate degeneration of intervertebral discs as the cause. In the normal intervertebral disc, the nucleus pulposus exerts a hydrostatic pressure against the constraining…

Human disk cells from degenerated disks and mesenchymal stem cells in co-culture result in increased matrix production.

Cells Tissues Organs. 2010;191(1):2-11 Authors: Svanvik T, Henriksson HB, Karlsson C, Hagman M, Lindahl A, Brisby H Transplantation of mesenchymal stem cells (MSCs) has been suggested for disk degeneration, which is characterized by dysfunctional cells and low proteoglycan production. The aim of this study was to examine the effects of a 3D co-culture system using…

Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells.

Mol Ther. 2009 Nov;17(11):1959-66 Authors: Yang F, Leung VY, Luk KD, Chan D, Cheung KM Degenerative disc disease (DDD) is a common disease which affects millions of people. Autograft of the bone marrow derived mesenchymal stem cells (BMSCs) have been shown to have the ability to arrest degeneration in rabbit and canine intervertebral discs. In…

Nucleus pulposus tissue engineering: a brief review.

Eur Spine J. 2009 Nov;18(11):1564-72 Authors: Yang X, Li X Symptomatic intervertebral disc degeneration is associated with several spinal diseases, which cause losses of life quality and money. Tissue engineering provides a promising approach to recover the functionality of the degenerative intervertebral disc. Most studies are directed toward nucleus pulposus (NP) tissue engineering because disc…

Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma.

Biomaterials. 2009 Oct;30(29):5523-33 Authors: Chen WH, Liu HY, Lo WC, Wu SC, Chi CH, Chang HY, Hsiao SH, Wu CH, Chiu WT, Chen BJ, Deng WP An ex vivo degenerative intervertebral disc (IVD) organ culture system was established for the screening of disc regeneration agents. Its application was demonstrated by a stem cell and growth…