Advances of nucleus pulposus cells for treating intervertebral disc degeneration

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul;23(7):864-7 Authors: Wang F, Wang Y, Wu X OBJECTIVE: To introduce the research of nucleus pulposus cells for treating intervertebral disc degeneration. METHODS: The original articles in recent years about nucleus pulposus cells for treating intervertebral disc degeneration were extensively reviewed, and retrospective and comprehensive…

Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: experiments in a canine model.

Spine (Phila Pa 1976). 2009 Oct 1;34(21):2297-304 Authors: Ganey T, Hutton WC, Moseley T, Hedrick M, Meisel HJ STUDY DESIGN: Therapeutic treatment of intervertebral disc repair using cells. OBJECTIVE: The goal of the study was to test the hypothesis that repair of a damaged disc is possible using autologous adipose tissue derived stem and regenerative…

Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells.

J Orthop Res. 2010 May;28(5):623-30 Authors: Watanabe T, Sakai D, Yamamoto Y, Iwashina T, Serigano K, Tamura F, Mochida J Activated nucleus pulposus (NP) cells can be reinserted into the disc to inhibit intervertebral disc degeneration. Experimental studies in animals showed that using a coculture system with direct cell-to-cell contact with mesenchymal stem cells (MSCs)…

Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs.

Eur Spine J. 2010 Apr;19(4):601-12 Authors: Omlor GW, Bertram H, Kleinschmidt K, Fischer J, Brohm K, Guehring T, Anton M, Richter W Intervertebral disc (IVD) degeneration involves a series of biochemical and morphological changes leading to loss of spinal stability and flexibility. Cell therapy is promising to reconstitute IVDs with new cells, however, sustained metabolic…

Bone morphogenetic proteins in soft-tissue reconstruction.

Injury. 2009 Dec;40 Suppl 3:S17-20 Authors: Obert L, Lepage D, Gindraux F, Garbuio P Different options are reviewed in the field of musculoskeletal tissue reconstruction, from the addition of biological actors (cells, growth factors, biological or artificial scaffolds) to the application of gene therapy or tissue engineering. Growth factors can enable innovative solutions to treat…

Disc regeneration therapy using marrow mesenchymal cell transplantation: a report of two case studies.

Spine (Phila Pa 1976). 2010 May 15;35(11):E475-80 Authors: Yoshikawa T, Ueda Y, Miyazaki K, Koizumi M, Takakura Y STUDY DESIGN: Marrow mesenchymal cells (MSCs) contain stem cells and possess the ability to regenerate bone, cartilage, and fibrous tissues. Here, we applied this regenerative ability to intervertebral disc regeneration therapy in an attempt to develop a…

Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combined therapy on reversing degeneration of the intervertebral disc.

J Bone Joint Surg Br. 2010 May;92(5):726-36 Authors: Hee HT, Ismail HD, Lim CT, Goh JC, Wong HK Although success has been achieved with implantation of bone marrow mesenchymal stem cells (bMSCs) in degenerative discs, its full potential may not be achieved if the harsh environment of the degenerative disc remains. Axial distraction has been…

Intervertebral disc regeneration: influence of growth factors on differentiation of human mesenchymal stem cells (HMSC).

Int J Artif Organs. 2010 Apr;33(4):244-52 Authors: Ehlicke F, Freimark D, Heil B, Dorresteijn A, Czermak P INTRODUCTION: One common cause of disability in modern society is low back pain. The main reason for this pain is the degeneration of the intervertebral disc (IVD), particularly of the nucleus pulposus (NP). For the early degeneration stage,…