Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model.

J Orthop Res. 2010 Oct;28(10):1267-1275 Authors: Serigano K, Sakai D, Hiyama A, Tamura F, Tanaka M, Mochida J Transplantation of mesenchymal stem cells (MSCs) inhibits the progression of disc degeneration in animal models. We know of no study to determine the optimal number of cells to transplant into the degenerated intervertebral disc (IVD). To determine…

Ossification of the Posterior Longitudinal Ligament of the Lumbar Spine: A Case Series.

Neurosurgery. 2010 Sep 23; Authors: Okada S, Maeda T, Saiwai H, Ohkawa Y, Shiba K, Iwamoto Y BACKGROUND:: Reports on ossification of the posterior longitudinal ligament (OPLL) of the lumbar spine have so far been limited. OBJECTIVE:: To evaluate surgically documented cases of lumbar OPLL at our facility to clarify its characteristics and analyze clinical…

Periurethral injection of autologous fat for the treatment of sphincteric incontinence.

J Urol. 1994 Mar;151(3):607-11. Periurethral injection of autologous fat for the treatment of sphincteric incontinence. Santarosa RP, Blaivas JG. Source Squire Urologic Clinic, Columbia-Presbyterian Medical Center, New York, New York. Abstract A total of 15 women with stress incontinence and 6 men with post-prostatectomy sphincteric incontinence underwent periurethral injection of autologous fat while under local…

Endoscopic treatment of sphincter insufficiency with autologous fat injection

Arch Ital Urol Androl. 1994 Sep;66(4 Suppl):219-24. [Endoscopic treatment of sphincter insufficiency with autologous fat injection]. [Article in Italian] Cervigni M, Tomiselli G, Perricone C, Panei M. Source Unità di Urologia Ginecologica Ospedale S. Carlo di Nancy, Roma. Abstract A total of 11 women with stress urinary incontinence related to intrinsic sphinteric incontinence (type 3)…

Periurethral injection of autologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: report of two initial cases.

Int J Urol. 2010 Jan;17(1):75-82. Epub 2009 Nov 30. Periurethral injection of autologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: report of two initial cases. Yamamoto T, Gotoh M, Hattori R, Toriyama K, Kamei Y, Iwaguro H, Matsukawa Y, Funahashi Y. Source Department of Urology, Nagoya University…

Regulation of TNFalpha and IL1beta in rheumatoid arthritis synovial fibroblasts by leukotriene B4.

Rheumatol Int. 2010 Jul;30(9):1183-9 Authors: Xu S, Lu H, Lin J, Chen Z, Jiang D Arachidonic acid metabolites, such as leukotriene B4 (LTB4), are known to play an important role in pathogenesis of rheumatoid arthritis (RA). Apart from leukocytes, RA synovial fibroblasts (RASF) produce a broad array of inflammatory mediators to recruit, retain and activate…

Monoclonal antibodies: new therapeutic agents for autoimmune hemolytic anemia?

Endocr Metab Immune Disord Drug Targets. 2008 Mar;8(1):62-8 Authors: D’Arena G, Taylor RP, Cascavilla N, Lindorfer MA Conventional treatment of autoimmune hemolytic anemia (AIHA) comprises corticosteroids and splenectomy and/or other immunosuppressive drugs for refractory/relapsed patients. Monoclonal antibodies (MoAbs) rituximab and alemtuzumab have gained widespread acceptance in the management of B-cell malignancies. More recently, they have…

Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts.

Biochem Biophys Res Commun. 2008 Jun 13;370(4):599-602 Authors: Palmer CD, Mutch BE, Page TH, Horwood NJ, Foxwell BM Discordant cytokine production is characteristic of chronic inflammatory conditions like rheumatoid arthritis (RA), and anti-cytokine therapeutics are becoming routinely used to treat RA in the clinic. Fibroblasts from rheumatoid synovium have been shown to contribute to cytokine…

Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways.

Mod Rheumatol. 2008;18(4):366-78 Authors: Okuma-Yoshioka C, Seto H, Kadono Y, Hikita A, Oshima Y, Kurosawa H, Nakamura K, Tanaka S We previously reported that synovial fibroblast-like cells (SFs) can be differentiated into chondrocytes through activin receptor-like kinase (ALK) 3 activation. The aim of this study was to clarify the effect and signaling pathways of tumor…