Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis.

Neurobiol Dis. 2008 Sep;31(3):395-405. Epub 2008 Jun 4. Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. Vercelli A, Mereuta OM, Garbossa D, Muraca G, Mareschi K, Rustichelli D, Ferrero I, Mazzini L, Madon E, Fagioli F. Department of Anatomy, Pharmacology and Forensic Medicine,…

Amyotrophic lateral sclerosis: clinical management and research update.

Curr Neurol Neurosci Rep. 2009 Jan;9(1):59-68. Amyotrophic lateral sclerosis: clinical management and research update. Andrews J. The Neurological Institute of New York, 710 West 168th Street, New York, NY 10032, USA. ja2289@columbia.edu Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that selectively affects the motor neurons of the brain and spinal cord. ALS…

Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery.

Growth Factors. 2009 Jun;27(3):133-40. Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery. Lunn JS, Hefferan MP, Marsala M, Feldman EL. Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, USA. Abstract Amyotrophic lateral sclerosis (ALS) is characterized by loss of both upper and lower motor neurons. ALS progression…

Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice.

Gene Ther. 2009 Oct;16(10):1234-44. Epub 2009 Jul 23. Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Hwang DH, Lee HJ, Park IH, Seok JI, Kim BG, Joo IS, Kim SU. Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea.…

Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up.

Cytotherapy. 2009;11(1):18-25. Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. Deda H, Inci MC, Kürekçi AE, Sav A, Kayihan K, Ozgün E, Ustünsoy GE, Kocabay S. Department of Neurosurgery and Neurology, Akay Hospital, Ankara, Turkey. halukdeda@gmail.com Comment in: Cytotherapy. 2009;11(2):256-7; author reply 258. Abstract BACKGROUND: Amyotrophic…

Adult stem cells for the treatment of neurological disease.

Methods Mol Biol. 2009;549:17-32. Adult stem cells for the treatment of neurological disease. Rice CM, Scolding NJ. University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK. Abstract The characteristic CNS responses to injury including increased cell production and attempts at regenerative repair – implicitly predicted where not directly demonstrated by Cajal, but only…

Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis.

Curr Stem Cell Res Ther. 2009 Sep;4(3):178-99. Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis. Thonhoff JR, Ojeda L, Wu P. Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-0620, USA. Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the selective loss of both…

Stem cells in amyotrophic lateral sclerosis: state of the art.

Expert Opin Biol Ther. 2009 Oct;9(10):1245-58. Stem cells in amyotrophic lateral sclerosis: state of the art. Mazzini L, Vercelli A, Ferrero I, Mareschi K, Boido M, Servo S, Oggioni GD, Testa L, Monaco F, Fagioli F. Eastern Piedmont University, Maggiore della Carità Hospital, ALS Centre, Department of Neurology, Corso Mazzini 18, Novara 28100, Italy. mazzini.l@libero.it…

Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis.

Brain Res. 2009 Nov 3;1296:216-24. Epub 2009 Aug 15. Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis. Ohnishi S, Ito H, Suzuki Y, Adachi Y, Wate R, Zhang J, Nakano S, Kusaka H, Ikehara S. Department of Neurology, Kansai…

Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients.

Cytotherapy. 2009;11(1):26-34. Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. Martinez HR, Gonzalez-Garza MT, Moreno-Cuevas JE, Caro E, Gutierrez-Jimenez E, Segura JJ. Servicio de Neurologia, Hospital Universitario UANL, Monterrey, Mexico. drhectormtz@yahoo.com Abstract BACKGROUND AIMS: Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons. CD133(+) stem cells are…