Multipotent mesenchymal stromal cells in articular diseases.

Best Pract Res Clin Rheumatol. 2008 Apr;22(2):269-84 Authors: Jorgensen C, Djouad F, Bouffi C, Mrugala D, Noël D Although cartilage defects are common features of osteoarthritis and rheumatoid arthritis, current treatments can rarely restore the full function of native cartilage. Recent studies have provided new perspectives for cartilage engineering using multipotent mesenchymal stromal cells (MSC).…

Evaluation of COX-1/COX-2 selectivity and potency of a new class of COX-2 inhibitors.

Eur J Pharmacol. 2008 Jun 24;588(1):93-8 Authors: Gierse J, Nickols M, Leahy K, Warner J, Zhang Y, Cortes-Burgos L, Carter J, Seibert K, Masferrer J A new class of selective cyclooxygenase-2 (COX-2) inhibitors has been identified by high throughput screening. Structurally distinct from previously described selective COX-2 inhibitors, these benzopyrans contain a carboxylic acid function…

Effects of a tetramethoxyhydroxyflavone p7f on the expression of inflammatory mediators in LPS-treated human synovial fibroblast and macrophage cells.

J Microbiol Biotechnol. 2008 Apr;18(4):686-94 Authors: Yoon DY, Cho MC, Kim JH, Kim EJ, Kang JW, Seo EH, Shim JH, Kim SH, Lee HG, Oh GT, Hong JT, Park JW, Kim JW The inhibitory effects of 5,6,3′,5′-tetramethoxy 7,4′-hydroxyflavone (labeled as p7F) were elucidated on the productions of proinflammatory cytokines as well as inflammatory mediators in…

Technology insight: adult mesenchymal stem cells for osteoarthritis therapy.

Nat Clin Pract Rheumatol. 2008 Jul;4(7):371-80 Authors: Nöth U, Steinert AF, Tuan RS Despite the high prevalence and morbidity of osteoarthritis (OA), an effective treatment for this disease is currently lacking. Restoration of the diseased articular cartilage in patients with OA is, therefore, a challenge of considerable appeal to researchers and clinicians. Techniques that cause…

Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts.

Inflamm Res. 2008 Jun;57(6):260-5 Authors: Lu Y, Wang WJ, Leng JH, Cheng LF, Feng L, Yao HP OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF). MATERIALS AND METHODS: RASF were obtained from the synovial tissue of…

Treatment of central nervous system involvement associated with primary Sjögren’s syndrome.

Curr Pharm Des. 2008;14(13):1270-3 Authors: Ozgocmen S, Gur A Sjögren’s syndrome (SS) is a chronic autoimmune disease that mainly affects the exocrine glands and usually presents with sicca symptoms of the main mucosal surfaces. The prevalence and the type of central nervous system (CNS) tissue damage caused by SS are debatable. The wide spectrum of…

Fetal cells of mesenchymal origin in cultures derived from synovial tissue and skin of patients with rheumatoid arthritis.

Joint Bone Spine. 2008 Oct;75(5):563-6 Authors: Hromadnikova I, Zlacka D, Hien Nguyen TT, Sedlackova L, Zejskova L, Sosna A The transplacental cell transfer naturally takes place during pregnancy and occurs bi-directionally between the mother and fetus. Using real-time polymerase chain reaction (PCR) assay and sex determining region Y (SRY) gene as a marker, we examined…

Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.

Biochem Biophys Res Commun. 2008 Aug 22;373(2):181-5 Authors: Imada K, Lin N, Liu C, Lu A, Chen W, Yano M, Sato T, Ito A Aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 have been shown to play crucial roles in cartilage destruction in arthritic diseases, including rheumatoid arthritis and osteoarthritis. In this study,…