The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts.

Arthritis Rheum. 2008 Aug;58(8):2296-306 Authors: Laragione T, Brenner M, Mello A, Symons M, Gulko PS OBJECTIVE: The synovial fibroblast, or fibroblast-like synoviocyte (FLS), has a central role in pannus invasion and destruction of cartilage and bone in rheumatoid arthritis (RA). However, regulation of the FLS remains incompletely understood. The aim of this study was to…

Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice.

Clin Exp Immunol. 2008 Aug;153(2):269-76 Authors: Choi JJ, Yoo SA, Park SJ, Kang YJ, Kim WU, Oh IH, Cho CS Mesenchymal stem cells (MSCs) have the inherent ability to migrate to multiple organs and to exert immunosuppressive activity. The aim of this study was to investigate the anti-arthritogenic effects of interleukin (IL)-10-transduced MSCs (IL-10-MSC) on…

A PEGylated Fab’ fragment against tumor necrosis factor for the treatment of Crohn disease: exploring a new mechanism of action.

BioDrugs. 2008;22(5):331-7 Authors: Bourne T, Fossati G, Nesbitt A Antibodies, having a high specificity for their particular target, are increasingly being used as therapeutic agents with functions including agonist, antagonist, and targeted drug delivery. The use of many biologic therapies, including antibody fragments, is generally limited by their rapid clearance from plasma. A commonly used…

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14692-7 Authors: Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE Regulation of IL-6 transsignaling by the administration of soluble gp130 (sgp130) receptor to capture the IL-6/soluble IL-6R complex has shown promise for the treatment of rheumatoid arthritis (RA).…

Inhibitory effect of synthetic cannabinoids on cytokine production in rheumatoid fibroblast-like synoviocytes.

Clin Exp Rheumatol. 2008 Jul-Aug;26(4):574-81 Authors: Selvi E, Lorenzini S, Garcia-Gonzalez E, Maggio R, Lazzerini PE, Capecchi PL, Balistreri E, Spreafico A, Niccolini S, Pompella G, Natale MR, Guideri F, Laghi Pasini F, Galeazzi M, Marcolongo R OBJECTIVE: To verify whether synthetic cannabinoids (CP55,940 and WIN55,212-2) are able to exert an anti-inflammatory effect on rheumatoid…

Cyclic thrombocytopenia complicated with Sjögren syndrome and the mechanism of periodic platelet count fluctuation

Rinsho Ketsueki. 2008 Aug;49(8):658-63 Authors: Yamauchi N, Muramatsu H, Inomata H, Numata T, Nozawa E, Nishino M, Koyama R, Ihara K, Nishisato T, Hirayama M, Katsuki S, Matsunaga T, Niitsu Y Cyclic thrombocytopenia is a rare disorder with periodic changes of the platelet count. We experienced a patient with cyclic thrombocytopenia and Sjögren syndrome (SS),…

Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells.

J Immunol. 2008 Oct 1;181(7):5111-9 Authors: Nochi H, Tomura H, Tobo M, Tanaka N, Sato K, Shinozaki T, Kobayashi T, Takagishi K, Ohta H, Okajima F, Tamoto K While inflammatory cytokines are well-recognized critical factors for the induction of cyclooxygenase-2 (COX-2) in activated fibroblast-like synovial cells, the roles of biologically active components other than inflammatory…

Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation.

Arthritis Rheum. 2008 Oct;58(10):3051-62 Authors: Vandooren B, Cantaert T, ter Borg M, Noordenbos T, Kuhlman R, Gerlag D, Bongartz T, Reedquist K, Tak PP, Baeten D OBJECTIVE: Cadherin 11 expressed on fibroblast-like synoviocytes (FLS) plays a key role in normal synovial architecture. The purpose of this study was to examine the expression of cadherin 11…

Modulatory effects of inflammation and therapy on GDF-5 expression in rheumatoid arthritis synovium.

Scand J Rheumatol. 2008 Nov-Dec;37(6):401-9 Authors: Bramlage CP, Kaps C, Ungethüm U, Bramlage P, Koziolek M, Wessels J, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR, Häupl T OBJECTIVE: Growth differentiation factor-5 (GDF-5), a member of the transforming growth factor (TGF)-beta family, is involved in joint development during embryogenesis and has the potential…

Mesenchymal stem cells and immunomodulation: toward new immunosuppressive strategies for the treatment of autoimmune diseases?

Rev Med Interne. 2009 Mar;30(3):287-99 Authors: Larghero J, Vija L, Lecourt S, Michel L, Verrecchia F, Farge D Mesenchymal stem cells (MSC) represent a population of the bone marrow microenvironment, which participates in the regulation of haematopoietic stem cells (HSC) self-renewal and differentiation. MSC are multipotent non-haematopoietic progenitors, which have been explored as a promising…