Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells.

Arthritis Rheum. 2009 Apr;60(4):1006-19 Authors: González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M OBJECTIVE: Rheumatoid arthritis (RA) is a chronic autoimmune disease caused by loss of immunologic self tolerance and characterized by chronic joint inflammation. Adult mesenchymal stem cells (MSCs) were recently found to suppress effector T cell responses and to have beneficial…

Quantitative measurement of cytokine expression in synoviocytes derived from rheumatoid arthritis patients.

Methods Mol Biol. 2009;512:233-48 Authors: Thomson S, Udalova IA Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by pain, swelling and progressive destruction of synovial joints. The synovial membranes of the affected joints markedly increase in size due to infiltration of several cell types, of which macrophages, lymphocytes and fibroblasts are most abundant. These…

Regenerative potential of human adult precursor cells: cell therapy–an option for treating cartilage defects?

Z Rheumatol. 2009 May;68(3):234-8 Authors: Dehne T, Tschirschmann M, Lauster R, Sittinger M Cell-based therapeutical approaches are already in clinical use and are attracting growing interest for the treatment of joint defects. Mesenchymal stem and precursor cells (MSC) cover a wide range of properties that are useful for the regeneration process of bone and cartilage…

Thrombin-sensitive photodynamic agents: a novel strategy for selective synovectomy in rheumatoid arthritis.

J Control Release. 2009 Sep 15;138(3):225-34 Authors: Gabriel D, Busso N, So A, van den Bergh H, Gurny R, Lange N Protease-sensitive macromolecular prodrugs have attracted interest for bio-responsive drug delivery to sites with up-regulated proteolytic activities such as inflammatory or cancerous lesions. Here we report the development of a novel polymeric photosensitizer prodrug (T-PS)…

Etanercept reduces the serum levels of macrophage chemotactic protein-1 in patients with rheumatoid arthritis.

Mod Rheumatol. 2009;19(4):372-8 Authors: Kageyama Y, Kobayashi H, Kato N, Shimazu M This study was performed to analyze the effect of etanercept, the soluble tumor necrosis factor-alpha (TNF-alpha) receptor, on the serum levels of several chemokines including monocyte chemotactic protein-1 (MCP-1), regulated upon activation normal T expressed and presumably secreted (RANTES), and granzyme B in…

Potentiation of glucocorticoid receptor (GR)-mediated signaling by the immunosuppressant tacrolimus in rheumatoid synoviocytes.

Clin Exp Rheumatol. 2009 Mar-Apr;27(2):246-52 Authors: Torigoshi T, Motokawa S, Miyashita T, Maeda Y, Koga T, Nakamura M, Komori A, Aiba Y, Uemura T, Yatsuhashi H, Ishibashi H, Eguchi K, Shindo H, Migita K OBJECTIVE: The immunosuppressant tacrolimus is known to enhance many aspects of glucocorticoid. In this study, we investigated the effects of tacrolimus…

Will Jill come tumbling after? The case for a JAK2-type mutation as a prequel to the connective tissue disorders.

Med Hypotheses. 2009 Nov;73(5):651-4 Authors: McQueen FM, Dalbeth N The JAK2 [V617F] mutation has recently been recognised as critical to the pathogenesis of the myeloproliferative disorders (MPDs). Thus, a common mutation affecting a haematopoietic precursor stem cell is capable of giving rise to diverse clinical phenotypes. In this hypothesis paper, we propose that a similar…

Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis.

J Immunol. 2009 Jun 15;182(12):8015-25 Authors: Kanayama M, Kurotaki D, Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suzuki K, Harada T, Li HM, Uehara J, Miyazaki T, Minami A, Kon S, Uede T Osteopontin is critically involved in rheumatoid arthritis; however, the molecular cross-talk between osteopontin…

Vasculopathy and pulmonary arterial hypertension.

Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii54-7 Authors: Guillevin L Vasculitis can occur either as a primary condition or secondary to CTDs, infection, medication or malignancy. This article reviews the clinical presentation and management of vascular disease associated with SLE and SS, as well as the primary necrotizing vasculitides. Although pulmonary arterial hypertension (PAH) has traditionally…