Autotaxin and lysophospholipids in rheumatoid arthritis.

Curr Opin Investig Drugs. 2010 May;11(5):515-26 Authors: Bourgoin SG, Zhao C Autotaxin (ATX) is an autocrine motility-stimulating factor and an extracellular enzyme that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA). Although ATX can also hydrolyze sphingosylphosphorylcholine (SPC) to sphingosine-1-phosphate (S1P), the major source of extracellular S1P originates from the intracellular phosphorylation of…

Salivary gland stem cells: Can they restore radiation-induced salivary gland dysfunction?]

HNO. 2010 Jun;58(6):556-63 Authors: Rotter N, Schwarz S, Jakob M, Brandau S, Wollenberg B, Lang S Adult stem cells are actively investigated in the fields of regenerative medicine and tissue engineering, as they exhibit specific characteristics that make them promising candidates for cellular therapies. Depending on their tissue of origin these characteristics include long-term proliferation…

Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton.

J Cell Biochem. 2010 Oct 1;111(2):249-57 Authors: Chanda D, Kumar S, Ponnazhagan S Mesenchymal stem cells (MSCs) are the most popular among the adult stem cells in tissue engineering and regenerative medicine. Since their discovery and functional characterization in the late 1960s and early 1970s, MSCs or MSC-like cells have been obtained from various mesodermal…

Autologous stromal vascular fraction cells: a tool for facilitating tolerance in rheumatic disease.

Cell Immunol. 2010;264(1):7-17 Authors: Ichim TE, Harman RJ, Min WP, Minev B, Solano F, Rodriguez JP, Alexandrescu DT, De Necochea-Campion R, Hu X, Marleau AM, Riordan NH Since the days of Medawar, the goal of therapeutic tolerogenesis has been a “Holy Grail” for immunologists. While knowledge of cellular and molecular mechanisms of this process has…

Overlapping juvenile idiopathic arthritis and systemic lupus erythematosus: a case report.

Rheumatol Int. 2010 Jul 30; Authors: Bazsó A, Sevcic K, Orbán I, Poór G, Balogh Z, Kiss E Hereby, we report the case of a 12-year-old girl developing oligoarthritis and progressing into a polyarticular form. Rheumatoid factor was positive, and juvenile idiopathic arthritis (JIA) was diagnosed. After a poor response to DMARDs, an anti-TNF agent…

Mesenchymal stem cells in arthritis: role of bone marrow microenvironment.

Arthritis Res Ther. 2010;12(4):135 Authors: Jorgensen C Based on their capacity to suppress immune responses, multipotent mesenchymal stromal cells (MSCs) are intensively studied for regenerative medicine. Moreover, MSCs are potent immunomodulatory cells that occur through the secretion of soluble mediators including nitric oxide, transforming growth factor beta, and HLAG5. The MSCs, however, are also able…

Does the KIR2DS5 gene protect from some human diseases?

PLoS One. 2010;5(8):e12381 Authors: Nowak I, Majorczyk E, WiÅ›niewski A, Pawlik A, Magott-Procelewska M, Passowicz-MuszyÅ„ska E, Malejczyk J, PÅ‚oski R, Giebel S, Barcz E, ZoÅ„-Giebel A, Malinowski A, Tchórzewski H, Chlebicki A, Łuszczek W, Kurpisz M, GryboÅ› M, WilczyÅ„ski J, Wiland P, Senitzer D, Sun JY, Jankowska R, Klinger M, KuÅ›nierczyk P BACKGROUND: KIR2DS5 gene…

A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke.

Cells. 2010 Jun;28(6):1099-106 A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. • Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY, • We previously evaluated the short-term follow-up preliminary data of mesenchymal stem cells (MSCs) transplantation in patients with ischemic stroke. The present study…

• Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats.

• J Transl Med. 2010;8:63 • Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. • Leu S, Lin YC, Yuen CM, Yen CH, Kao YH, Sun CK, Yip HK • BACKGROUND: The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status…

Stem cell transplantation for ischemic stroke.

Cochrane Database Syst Rev. 2010;9:CD007231 Stem cell transplantation for ischemic stroke. Boncoraglio GB, Bersano A, Candelise L, Reynolds BA, Parati EA BACKGROUND: Studies in animal models of ischemic stroke have shown that stem cells transplanted into the brain can lead to functional improvement. However, to date, evidence for the benefits of stem cell transplantation in…