Intravenous implanted neural stem cells migrate to injury site, reduce infarct volume, and improve behavior after cerebral ischemia.

Curr Neurovasc Res. 2010 Aug 1;7(3):167-79. Intravenous implanted neural stem cells migrate to injury site, reduce infarct volume, and improve behavior after cerebral ischemia. Shen CC, Lin CH, Yang YC, Chiao MT, Cheng WY, Ko JL. Source Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan. Abstract Stroke represents one of the leading causes of…

Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia.

Stroke. 2010 Sep;41(9):2064-70. Epub 2010 Jul 8. Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia. Pendharkar AV, Chua JY, Andres RH, Wang N, Gaeta X, Wang H, De A, Choi R, Chen S, Rutt BK, Gambhir SS, Guzman R. Source Department of Neurosurgery, Stanford University, School of Medicine, Stanford, CA 94305-5327, USA. Abstract…

Isolation and perivascular localization of mesenchymal stem cells from mouse brain.

Neurosurgery. 2010 Sep;67(3):711-20. Isolation and perivascular localization of mesenchymal stem cells from mouse brain. Kang SG, Shinojima N, Hossain A, Gumin J, Yong RL, Colman H, Marini F, Andreeff M, Lang FF. Source Department of Neurosurgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA. Abstract BACKGROUND: Although originally isolated from the…

Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke.

J Transl Med. 2010 Aug 20;8:77. Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke. Sun C, Zhang H, Li J, Huang H, Cheng H, Wang Y, Li P, An Y. Source Department of Neural Stem Cell, Beijing Neurosurgical Institute, Beijing Tiantan…

Intravenous infusion of GDNF gene-modified human umbilical cord blood CD34+ cells protects against cerebral ischemic injury in spontaneously hypertensive rats.

Brain Res. 2010 Dec 17;1366:217-25. Epub 2010 Oct 1. Intravenous infusion of GDNF gene-modified human umbilical cord blood CD34+ cells protects against cerebral ischemic injury in spontaneously hypertensive rats. Ou Y, Yu S, Kaneko Y, Tajiri N, Bae EC, Chheda SH, Stahl CE, Yang T, Fang L, Hu K, Borlongan CV, Yu G. Source Department…

Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model.

J Neurosci Res. 2010 Nov 15;88(15):3282-94. Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model. Lee HJ, Lim IJ, Lee MC, Kim SU. Source Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea. Abstract Intracerebral hemorrhage (ICH) is a lethal stroke type;…

Critical questions for preclinical trials on safety and efficacy of vascular endothelial growth factor-based therapeutic angiogenesis for ischemic stroke.

CNS Neurol Disord Drug Targets. 2011 Mar;10(2):215-34. Critical questions for preclinical trials on safety and efficacy of vascular endothelial growth factor-based therapeutic angiogenesis for ischemic stroke. Manoonkitiwongsa PS. Source Neural Engineering Program, Huntington Medical Research Institutes, Pasadena, CA, USA. stevemanoon@hotmail.com Abstract Therapeutic angiogenesis is a novel treatment for ischemic stroke, and vascular endothelial growth factor…

Progress and prospects: stem cells and neurological diseases.

Gene Ther. 2011 Jan;18(1):1-6. Epub 2010 Sep 30. Progress and prospects: stem cells and neurological diseases. Gögel S, Gubernator M, Minger SL. Source Wolfson Centre for Age-Related Diseases, Guy’s Campus, King’s College London, London, UK. stefanie.gogel@kcl.ac.uk Abstract The central nervous system has limited capacity of regenerating lost tissue in slowly progressive, degenerative neurological conditions such…

Vascular protection and restorative therapy in ischemic stroke.

Cell Transplant. 2011;20(1):95-7. Epub 2010 Sep 30. Vascular protection and restorative therapy in ischemic stroke. Yamashita T, Deguchi K, Nagotani S, Abe K. Source Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Abstract Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring…