Retinal stem cells transplanted into models of late stages of retinitis pigmentosa preferentially adopt a glial or a retinal ganglion cell fate.

Invest Ophthalmol Vis Sci. 2007 Jan;48(1):446-54. Retinal stem cells transplanted into models of late stages of retinitis pigmentosa preferentially adopt a glial or a retinal ganglion cell fate. Canola K, Angénieux B, Tekaya M, Quiambao A, Naash MI, Munier FL, Schorderet DF, Arsenijevic Y. Source Unit of Gene Therapy and Stem Cell Biology, Jules Gonin Eye Hospital, 1004 Lausanne, Switzerland. Abstract PURPOSE: To…

Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6394-400. Epub 2010 Oct 6. Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection. Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S. Source Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine,…

Nanotechnology in ocular drug delivery.

Drug Discov Today. 2008 Feb;13(3-4):144-51. Nanotechnology in ocular drug delivery. Sahoo SK, Dilnawaz F, Krishnakumar S. Source Laboratory of Nanomedicine, Institute of life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar 751 023, India. sanjeebsahoo2005@gmail.com Abstract Despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Most ocular diseases are treated by topical drug…

Retinal incorporation and differentiation of mesenchymal stem cells intravitreally injected in the injured retina of rats.

Arq Bras Oftalmol. 2008 Sep-Oct;71(5):644-50. Retinal incorporation and differentiation of mesenchymal stem cells intravitreally injected in the injured retina of rats. Castanheira P, Torquetti L, Nehemy MB, Goes AM. Source Department of Biochemistry, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Abstract PURPOSE: To evaluate the pattern of retinal integration and…

Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6394-400. Epub 2010 Oct 6. Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection. Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S. Source Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine,…

Cytokines in proliferative vitreoretinopathy.

Cytokines in proliferative vitreoretinopathy. Limb GA, Little BC, Meager A, Ogilvie JA, Wolstencroft RA, Franks WA, Chignell AH, Dumonde DC. Source Department of Immunology, St Thomas’ Hospital, UMDS, London. Abstract This study determined the presence of interleukin 1 (IL-1), interleukin 6 (IL-6), tumour necrosis factor alpha (TNF alpha), tumour necrosis factor beta (TNF beta), interferon…

Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis.

Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Otani A, Kinder K, Ewalt K, Otero FJ, Schimmel P, Friedlander M. Source Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA. Abstract Adult bone marrow (BM) contains cells capable of differentiating along hematopoietic (Lin(+)) or non-hematopoietic (Lin(-))…

Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells.

Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. Otani A, Dorrell MI, Kinder K, Moreno SK, Nusinowitz S, Banin E, Heckenlively J, Friedlander M. Source Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA. Abstract Inherited retinal degenerations afflict 1 in 3,500 individuals and are…

Ex vivo gene therapy using intravitreal injection of GDNF-secreting mouse embryonic stem cells in a rat model of retinal degeneration.

Ex vivo gene therapy using intravitreal injection of GDNF-secreting mouse embryonic stem cells in a rat model of retinal degeneration. Gregory-Evans K, Chang F, Hodges MD, Gregory-Evans CY. Source Department of Clinical Neuroscience, Faculty of Medicine, Imperial College London, London, UK. k.gregory-evans@imperial.ac.uk Abstract PURPOSE: Safe and prolonged drug delivery to the retina is a key…