Stem cell and gene therapeutic strategies for the treatment of multiple sclerosis.

2009 Nov;9(8):992-1016 Stem cell and gene therapeutic strategies for the treatment of multiple sclerosis. Siatskas C, Bernard CC Abstract Multiple sclerosis is a disease of the central nervous system that predominantly affects young adults. The pathogenic mechanisms are complex, however numerous studies indicate that the disease is initiated by an autoimmune attack on protein targets…

Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis.

2009 Oct; 27(10) : 2624-35 Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis. Constantin G, Marconi S, Rossi B, Angiari S, Calderan L, Anghileri E, Gini B, Bach SD, Martinello M, Bifari F, Galiè M, Turano E, Budui S, Sbarbati A, Krampera M, Bonetti B Abstract Mesenchymal stem cells (MSCs) represent a promising therapeutic…

Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo.

2009 Sep;110(5):1674-84 Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. Lanza C, Morando S, Voci A, Canesi L, Principato MC, Serpero LD, Mancardi G, Uccelli A, Vergani L Abstract Experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis, is characterized by demyelination, inflammation and neurodegeneration of CNS in…

Stem cell-based cell therapy in neurological diseases: a review.

2009 Aug 1;87(10):2183-200. Stem cell-based cell therapy in neurological diseases: a review. Kim SU, de Vellis J. Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada. sukim@interchange.ubc.ca Abstract Human neurological disorders such as Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, multiple sclerosis (MS), stroke, and…

Regeneration and repair in multiple sclerosis: the role of cell transplantation.

2009 Jun 12; 456(3) : 101-6. Epub 2009 Jan 17. Regeneration and repair in multiple sclerosis: the role of cell transplantation. Pluchino S, Zanotti L, Brini E, Ferrari S, Martino G. Neuroimmunology Unit and Institute of Experimental Neurology (INSpe), DIBIT-San Raffaele Scientific Institute, via Olgettina 58, 20123 Milano, Italy. Abstract Physiological (spontaneous) and reactive (reparative)…

Multiple sclerosis: Hematopoietic stem cell transplantation: hope and hype.

2009 Jun;5(6):300-2 Multiple sclerosis: Hematopoietic stem cell transplantation: hope and hype. Stangel M Abstract A trial of autologous hematopoietic stem cell transplantation to treat multiple sclerosis has yielded promising results, generating considerable interest within both the clinical literature and the mainstream press.the findings should, however, be interpreted with some caution, and larger, randomized trials will…

Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies.

2008 Dec; 2(4) : 699-705 Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies. Greco SJ, Rameshwar P Abstract The therapeutic utilization of stem cells has been ongoing for several decades, principally in the form of bone marrow (BM) transplants to treat various hematological disorders and other immune-related diseases. More recently,…

The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience.

2008 Nov; 110(9) : 889-96. Epub 2008 Mar 28. The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience. Karussis D, Kassis I. Department of Neurology, Laboratory of Neuroimmunology, Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Hospital, Ein-Karem, Jerusalem, Israel. karus@cc.huji.ac.il Abstract The reported neurodegeneration process in multiple sclerosis may explain…