Cell Based Therapy For ED

Stem and endothelial progenitor cells in erection biology. Strong TD, Gebska MA, Champion HC, Burnett AL, Bivalacqua TJ. Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an erection forsatisfactory sexual relations. The past 20 years of basic science research on erection physiology has been devoted to investigating the pathogenesis of…

Cells Into Smooth Muscle Cells

Gonzalez-Cadavid NF: Effect of muscle-derived stem cells on the restoration of corpora cavernosansmooth muscle and erectile function in the aged rat. Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, OBJECTIVE: To determine whether skeletal muscle-derived stem cells (MDSCs) convert into smooth muscle cells (SMCs) both in vitro…

Andrology-Related Stem Cell

Recent advances in andrology-related stem cell research. Lin CS, Xin ZC, Deng CH, Ning H, Lin G, Lue TF Abstract Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells (BSC) have greater differentiation potential than adult stem cells, the…

ED & Endothelial Dysfunction

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction. Strong TD, Gebska MA, Burnett AL, Champion HC, Bivalacqua TJ. Abstract Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for…

Neurogenic Erectile Dysfunction

10(1):54-9 Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury. Bella AJ, Lin G, Cagiannos I, Lue TF. Abstract Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies…

Penile Rehabilitation Therapy

594868 Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radicalbprostatectomy. Albersen M, Joniau S, Claes H, Van Poppel H Abstract Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional…

Lower Urinary Tract

52(6):1580-9 Tissue engineering for the lower urinary tract: a review of a state of the art approach. Sievert KD, Amend B, Stenzl A Abstract OBJECTIVES: Tissue engineering (TE) has become synonymous with physiological and functional reconstructive approaches in medicine. Although the goals of TE are ambitious and have not yet been attained, significant milestones have…

Monitoring Cells with MRI

9(3):361-7. Magnetic resonance evaluation of human mesenchymal stem cells in corpus cavernosa of rats and rabbits. Song YS, Ku JH, Song ES, Kim JH, Jeon JS, Lee KH, Kim SJ, Cheong HJ, Lim IS, Choi D, Won JH Abstract AIM: To investigate whether the biological process of superparamagnetic iron oxide (SPIO)-labeled human mesenchymal stem cells…

ED & Vascular Damage

51(5):1411-7; discussion 1417-9 Relationship between vascular damage degrees and endothelial progenitor cells in patients with erectile dysfunction: effect of vardenafil administration and PDE5 expression in the bone marrow. Foresta C, Caretta N, Lana A, De Toni L, Biagioli A, Vinanzi C, Ferlin A: Abstract OBJECTIVES: To evaluate the levels of circulating progenitor cells (PCs) and…