Endothelial Dysfunction

2007 Apr;7(2):131-53 Gene and stem cell therapy in the treatment of erectile dysfunction and pulmonary hypertension; potential treatments for the common problem of endothelial dysfunction. Nossaman BD, Gur S, Kadowitz PJ. Abstract The endothelium has an important regulatory role in the maintenance of vascular homeostasis, vascular tone, blood flow, and in preserving a non-thrombogenic blood-tissue…

Age-Associated Erectile Dysfunction.

2007 Mar;292(3):H1278-90. Epub 2006 Oct Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Bivalacqua TJ, Deng W, Kendirci M, Usta MF, Robinson C, Taylor BK, Murthy SN, Champion HC, Hellstrom WJ, Kadowitz PJ. Abstract Mesenchymal stem cells (MSCs) can be used in adult stem cell-based…

Endothelial Function in ED

2006 Sep-Oct;18(5):484-8 Circulating endothelial progenitor cells and endothelial function after chronic Tadalafil treatment in subjects with erectile dysfunction. Foresta C, Ferlin A, De Toni L, Lana A, Vinanzi C, Galan A, Caretta N. Abstract We evaluated the effect of a chronic treatment with Tadalafil on progenitor cells (PCs) number and endothelial function in patients with…

Regenerative Cell Therapy

2006 Apr;13(2):77-81. Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. Nakagami H, Morishita R, Maeda K, Kikuchi Y, Ogihara T, Kaneda Y. Abstract Adult stem cells hold great promise for use in tissue repair and regeneration, and the delivery of autologous progenitor cells into ischemic tissue is emerging as a novel…

Erectile Dysfunction

2005 Dec;17 Suppl 1:S57-63. Gene and stem cell therapy for erectile dysfunction. Deng W, Bivalacqua TJ, Hellstrom WJ, Kadowitz PJ Abstract Erectile dysfunction (ED) is defined as the inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance. ED is a highly prevalent health problem with considerable impact on the quality of life…

Erectile Function

2005 May;47(5):710-8; discussion 718-9. Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering. Pilatz A, Schultheiss D, Gabouev AI, Schlote N, Mertsching H, Jonas U, Stief CG. Abstract OBJECTIVES: Primary cell cultures derived from the corpus cavernosum are frequently used as in vitro models to…

ED & Cavernosal Tissue Function

2004 Mar-Apr;23(2-3):167-76. Therapy of erectile dysfunction: potential future treatments. Gonzalez-Cadavid NF, Rajfer J. Abstract Current research on the development of new medical treatments of erectile dysfunction (ED) fall essentially into two main types of approaches: (1) the traditional strategy based on compounds acting to induce an erection on demand, without modifying the underlying pathologic alterations…

Cavernosal Nerve Injury

2004 Oct;94(6):904-9. Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, Lue TF: The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. Abstract OBJECTIVE: To isolate embryonic stem cells that have differentiated along the neuronal cell line, and to assess whether injecting these neural stem…

Ischemia and Enhancing Circulation

2001 Feb 13;103(6):897-903. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Shintani S, Murohara T, Ikeda H, Ueno T, Sasaki K, Duan J, Imaizumi T. Cardiovascular Research Institute and the Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan. Abstract BACKGROUND: Endothelial progenitor cells (EPCs) have been identified in adult human…