Progress in Gene and Stem Cell Therapy

8(10):1521-38 A review of current progress in gene and stem cell therapy for erectile dysfunction. Gur S, Kadowitz PJ, Hellstrom WJ: Abstract BACKGROUND: Current gene-based strategies for treatment of erectile dysfunction (ED) are based on the nitric oxide (NO)/cGMP system; although growth factors, calcium sensitization, and potassium channel expression have been studied. Initial investigations of…

Repairing Erectile Dysfunction

102(2):220-4; discussion 224. Epub 2008 Jul 1. Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction. Song YS, Lee HJ, Park IH, Lim IS, Ku JH, Kim SU OBJECTIVE: To investigate the feasibility of applying neural crest stem cells (NCSCs), with multipotent capacity, to repair injury in the penile…

Cell Based Therapy For ED

Stem and endothelial progenitor cells in erection biology. Strong TD, Gebska MA, Champion HC, Burnett AL, Bivalacqua TJ. Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an erection forsatisfactory sexual relations. The past 20 years of basic science research on erection physiology has been devoted to investigating the pathogenesis of…

Cells Into Smooth Muscle Cells

Gonzalez-Cadavid NF: Effect of muscle-derived stem cells on the restoration of corpora cavernosansmooth muscle and erectile function in the aged rat. Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, OBJECTIVE: To determine whether skeletal muscle-derived stem cells (MDSCs) convert into smooth muscle cells (SMCs) both in vitro…

Andrology-Related Stem Cell

Recent advances in andrology-related stem cell research. Lin CS, Xin ZC, Deng CH, Ning H, Lin G, Lue TF Abstract Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells (BSC) have greater differentiation potential than adult stem cells, the…

ED & Endothelial Dysfunction

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction. Strong TD, Gebska MA, Burnett AL, Champion HC, Bivalacqua TJ. Abstract Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for…

Neurogenic Erectile Dysfunction

10(1):54-9 Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury. Bella AJ, Lin G, Cagiannos I, Lue TF. Abstract Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies…

Penile Rehabilitation Therapy

594868 Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radicalbprostatectomy. Albersen M, Joniau S, Claes H, Van Poppel H Abstract Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional…

Lower Urinary Tract

52(6):1580-9 Tissue engineering for the lower urinary tract: a review of a state of the art approach. Sievert KD, Amend B, Stenzl A Abstract OBJECTIVES: Tissue engineering (TE) has become synonymous with physiological and functional reconstructive approaches in medicine. Although the goals of TE are ambitious and have not yet been attained, significant milestones have…